Adjusted Cox models for all-cause mortality or cardiovascular hospitalisation
| Reduced EF (LVEF≤40%) | Preserved EF (LVEF>40%) | |||
|---|---|---|---|---|
| Variable | Adjusted HR (95% CI) | p Value | Adjusted HR (95% CI) | p Value |
| Male | 1.23 (0.96 to 1.58) | 0.10 | 0.92 (0.77 to 1.09) | 0.34 |
| Age (per 10 years) | 1.30 (1.17 to 1.44) | <0.01 | 1.24 (1.13 to 1.36) | <0.01 |
| High β-blocker dose | 0.96 (0.78 to 1.19) | 0.71 | 0.87 (0.73 to 1.03) | 0.11 |
| Low heart rate (<70 bpm) | 0.98 (0.79 to 1.22) | 0.84 | 1.00 (0.84 to 1.19) | 0.96 |
| Admission tachycardia (>120 bpm) | 0.67 (0.52 to 0.88) | <0.01 | 0.79 (0.64 to 0.98) | 0.04 |
| Previous MI | — | — | 1.34 (1.09 to 1.64) | <0.01 |
| COPD | 1.32 (1.05 to 1.67) | 0.02 | 1.31 (1.09 to 1.57) | <0.01 |
| Malignancy | 1.48 (1.07 to 2.06) | 0.02 | — | — |
| Chronic kidney disease | — | — | 1.33 (1.04 to 1.71) | 0.03 |
| Dyslipidaemia | 1.81 (1.45 to 2.27) | <0.01 | — | — |
| Liver disease | — | — | 2.21 (1.17 to 4.17) | 0.02 |
| Amiodarone use | 1.50 (1.17 to 1.91) | <0.01 | — | — |
| Digoxin use | 1.27 (1.01 to 1.59) | 0.04 | — | — |
| Haemoglobin (per g/L change) | 0.99 (0.98 to 1.00) | <0.01 | 0.99 (0.99 to 1.00) | <0.01 |
| WCC (per 10^9/L change) | 1.05 (1.01 to 1.09) | 0.03 | — | — |
| Creatinine (per 10 µmol/L change) | 1.04 (1.02 to 1.05) | <0.01 | — | — |
Variable excluded from final model due to non-significance.
Cardiovascular hospitalisation includes heart failure, acute coronary syndrome, atrial fibrillation and stroke. —: Variable excluded from final model due to non-significance. HRs for laboratory data and heart rate represent a change in one unit.
COPD, chronic obstructive pulmonary disease; LVEF, left ventricular ejection fraction; MI, myocardial infarction; WCC, white cell count.