Table 2

Cox regression model up to 8 years follow-up

Variable	HR	95% CI	p Value
Age/5 years	1.53	1.50 to 1.56	<0.001
Ejection fraction/5%	0.88	0.86 to 0.89	<0.001
Other significant disease	2.01	1.79 to 2.27	<0.001
Smoking	1.58	1.44 to 1.73	<0.001
Diabetes	1.41	1.30 to 1.54	<0.001
Previous CABG	1.12	1.00 to 1.25	0.047
Exercise ECG*
Negative exercise test	0.69	0.59 to 0.81	<0.001
Inconclusive result	0.79	0.72 to 0.87	<0.001
Ischaemic exercise response	0.67	0.61 to 0.73	<0.001
CCS function class 3 or 4†	1.31	1.21 to 1.42	<0.001
Number of diseased coronary arteries‡	1.19	1.13 to 1.26	<0.001
Presence of generalised arteriosclerosis	1.35	1.19 to 1.53	<0.001
Gender	1.14	1.06 to 1.23	0.001
Previous myocardial infarction	1.10	1.02 to 1.18	0.014
Treatment strategy§	1.29	0.86 to 1.93	0.23
Interaction term strategy and number of diseased vessel	0.84	0.72 to 0.97	0.02

*Included as three 0/1 indicator variables with the alternative ‘exercise test not performed’ as reference.
†Canadian function class included as a dichotomous variable: 0: class 0–2,1: class 3 or 4.
‡coded as 1, 2 and 3.
§coded as 0 for PCI and 1 for CABG.
CABG, coronary artery bypass grafting; CCS, Canadian Cardiovascular Society; PCI, percutaneous coronary intervention.