Table 1

Overview of studies exploring factors relating to adherence to OAPs, including study design, significant outcomes and measurement time points

	Study type, collection methods, sample size	Significant factors impacting non-adherence	Measurement time point (postdischarge; months)
Author, year, country	Study type, collection methods, sample size	Significant factors impacting non-adherence	1	3	6	12
Bally, 2012, Switzerland	Observational self-report (questionnaire to GPs and patients) n=204	Demographic Older age Treatment Side effects (experienced)			X	X
Blich, 2012, Israel	Observational self-report, interview with physician, medical record review n=314	Demographic ▸ Unemployed ▸ Ethnicity (non-Jew) ▸ Low socioeconomic status System process ▸ No referral to cardiologist at discharge ▸ No medication instruction at discharge		X
Deghani, 2014, Spain	Prospective, observational registry data review n=248	Demographic ▸ Older age ▸ Ethnicity (non-white) ▸ Female gender Clinical Prior cardiovascular procedure Treatment Side effects (experienced)				X
Ferreira-Gonzalez, 2010, Spain	Prospective self-report (interviews with patients), secondary care n=1622 (182 on clopidogrel)	Demographic Being an immigrant Treatment Concomitant drugs (psychotropic)				X
Gencer, 2015, Switzerland	Prospective self-report (interviews with patients), secondary care n=3055 (2597 on P2Y12 inhibitor)	Demographic Older age Treatment Side effects (experienced) Opportunity Cost Psychosocial Low treatment necessity				X
Kubica, 2015, Poland	Prospective, observational, prescription database review n=184	Demographic Male gender Clinical ▸ ADP-PA during hospitalisation ▸ STEMI ▸ 3-vessel CAD*			X
Melloni, 2009, USA	Prospective self-report (interviews with patients), secondary care n=1077 (816 on clopidogrel)	Demographic Lower level of education Clinical ▸ Prior cardiovascular procedure ▸ Comorbidities ▸ Less clinical follow-up Treatment Greater number of medicines at discharge Opportunity Cost Psychosocial Forgetting		X
Muntner, 2011, USA	Prospective self-report (interview with patient), secondary care n=285	Opportunity ▸ Cost ▸ Access/logistics Psychosocial ▸ Poor relationship with doctor ▸ Low adherence at baseline	X
Nordstrom, 2013, USA	Retrospective, prescription database review n=1340	Clinical ▸ Prior PCI* ▸ Prior depression* ▸ Prior bleeds* ▸ Pre-existing cardiovascular condition Psychosocial Low adherence at baseline Treatment ▸ Baseline statin use* ▸ Baseline anticoagulant use*				X
Pallares, 2009, USA	Prospective self-report (interview with patient), secondary care n=257	Clinical Prior cardiovascular procedure Treatment Side effects (experienced) System process No information at discharge Opportunity ▸ Cost ▸ Access/logistics Psychosocial ▸ Low treatment necessity ▸ Low understanding of treatment		X	X
Poh, 2009, Singapore	Prospective registry database review n=207	Demographic ▸ Not living with caregiver ▸ Being single Clinical Lower BMI				X
Shimony, 2010, Israel	Retrospective prescriptions database n=1397	Demographic Low socioeconomic status				X
Spertus, 2006, USA	Prospective self-report (patient interview), secondary care n=500	Demographic ▸ Older age ▸ Lower level of education Clinical ▸ Prior anaemia ▸ Pre-existing cardiovascular condition System process No information at discharge	X
Tuppin, 2010, France	Retrospective prescription database n=1056	Demographic Older age Treatment Prior use of clopidogrel* Clinical ▸ Comorbidities ▸ Stent implantation* Opportunity Cost			X
Zhu, 2011, USA	Retrospective prescription database n=10 465	Demographic Younger age Clinical ▸ Comorbidities ▸ PCI with no stent ▸ Prior hospitalisation for cardiovascular event Treatment Prior use of clopidogrel				X

*Associated with greater adherence.
ADP-PA, ADP-induced platelet aggregation; BMI, body mass index; CAD, coronary artery disease; GP, general practitioner; PCI, percutaneous coronary intervention; STEMI, ST segment elevation myocardial infarction.