Table 1

Health system arrangements investigated by included studies, classified by health system domain

Health system framework domainHealth system factor being investigatedNumber of studiesNumber of studies and study designsSetting of studies (countries)
Governance and deliveryPhysician-led education1RCT (1)UK (1)21
Nurse-led education3RCT (2)Denmark (1),22 UK (1)23
Cohort (1)USA/Canada (1)39
Pharmacy-led education2RCT (1)USA (1)17
Non-randomised trial (1)Germany (1)29
Comprehensive education programme2RCT (1)Turkey (1)24
Cohort (1)France (1)36
Hospital-level quality improvement4RCT (1)USA (1)19
Cohort (2)USA (1)30 Canada (1)31
Case–control (1)USA (1)41
Routine place of care1Cohort (1)Sweden (1)32
Generic versus branded drugs1Cohort (1)USA (1)37
Complexity of treatment regimen1Cross-sectional (1)Argentina/Brazil/Italy/Paraguay/Spain (1)25
FDC4RCT (4)India/Europe (1),20 Australia/New Zealand (1),26 New Zealand (1),28 Argentina/Brazil/Italy/Paraguay/Spain (1)25
All governance and delivery studies19RCT (10), non-randomised trial (1), cohort (6), cross-sectional (1), case–control (1)USA (5), Canada (1), USA/Canada (1), UK(2), Germany (1), Sweden (1), Turkey (1), France (1), Denmark (1), India/Europe (1), Australia/New Zealand (1), New Zealand (1), Argentina/Brazil/Italy/Paraguay/Spain (2)
Human resourcesUndergraduate training of physicians1Cohort (1)Canada (1)18
All human resources studies1Cohort (1)Canada (1)
Intellectual resourcesEducation of physicians1Cohort (1)Israel (1)33
All intellectual resources studies1Cohort (1)Israel (1)
Health system financingCopayments for medical care2Cohort (2)USA (1),35 Austria (1)34
Insurance and prescription cost assistance2Cohort (1)USA (1)38
RCT (1)USA (1)27
All financing studies4RCT (1), cohort (3)USA (3), Austria (1)
Physical resourcesAll physical resources studies0
Social resourcesAll social resources studies0
  • Italics denote the total number of studies under a particular health system domain. RCT, randomised controlled trial.