Table 2

Investigations performed in the ICON-1 study

InvestigationPerformedTime taken
Blood tests30 mL blood taken in cardiac catheterisation laboratory and at 1 year follow-upAs part of routine care
Invasive imaging:

  • ▸ Virtual histology intravascular ultrasound

  • ▸ Optical coherence tomography

In cardiac catheterisation laboratory15 min
Arterial stiffnessDay 1 post-PCI15 min
Endothelial functionDay 1 post-PCI15 min
Carotid intima media thickeningDay 1 post-PCI5 min
Transthoracic echocardiographyDay 1 post-PCI10 min
Frailty assessments:

  • ▸ Fried criteria

  • ▸ Rockwood criteria

Day 1 post-PCI and at 1 year follow-up5 min
Quality of life questionnaire:

  • EQ-5D

Day 1 post-PCI and at 1 year follow-up15 min
Cognitive assessment:

  • Montreal cognitive assessment

Day 1 post-PCI and at 1 year follow-up10 min

  • PCI, percutaneous coronary intervention.