Eligibility criteria for P, and appropriate choice of C or P at admission and at discharge in the four groups
| C N=2842 (69.3%) | P N=391 (9.5%) | Switch C to P N=678 (16.5%) | Switch P to C N=190 (4.6%) | |
|---|---|---|---|---|
| Loading dose of the initial P2Y12 (in mg) | C 75: 476 (17%) 150: 64 (2%) 300: 1361 (48%) 600: 851 (30%) >600: 16 (1%) ND: 74 (3%) | P 5: 2 (1%) 10: 46 (12%) 30: 10 (2%) 60: 325 (83%) ND: 8 (2%) | C 75: 49 (7%) 150: 6 (1%) 300: 322 (47%) 600: 253 (37%) >600: 12 (2%) ND: 36 (5%) | P 10: 109 (57%) 30: 9 (5%) 60: 47 (25%) ND: 25 (13%) |
| Loading dose of the final P2Y12 (in mg) | P 10: 397 (59%) 30: 23 (3%) 60: 56 (8%) ND: 202 (30%) | C 75: 31 (16%) 150: 4 (2%) 300: 51 (27%) 600: 78 (41%) 600: 3 (2%) ND: 23 (12%) | ||
| Intended PPCI* (STEMI) | 804 (28.3%) | 253 (64.7%) | 328 (48.4%) | 110 (57.9%) |
| History of TIA or stroke | 179 (6.3%) | 4 (1.0%) | 8 (1.2%) | 0 |
| Body weight≤60 kg | 361 (13.3%) | 12 (3.2%) | 16 (2.4%) | 13 (6.9%) |
| Age>75 years | 1149 (40.4%) | 11 (2.8%) | 34 (5.1%) | 7 (3.7%) |
| Eligible for P at admission† | 425 (14.9%) | 233 (59.6%) | 291 (42.9%) | 98 (51.6%) |
| No PCI (all MIs) | 782 (27.5%) | 27 (6.9%) | 33 (4.9%) | 14 (7.4%) |
| Eligible for P at discharge‡ | 1119 (39.4%) | 327 (83.6%) | 584 (86.1%) | 156 (82.1%) |
| §Appropriate use of switch | 584 (86%) | 38 (20%) |
*Intended PPCI: patients admitted for STEMI for whom reperfusion with primary angioplasty was intended.
†Eligible for P at admission: patients with acute coronary syndrome, body weight>60 kg, age<76 years, without history of stroke or TIA and intended for PPCI.
‡Eligible for P at discharge: patients with acute coronary syndrome, treated with PCI, age<76 years, body weight>60 kg, without history of stroke or TIA, and with no major or moderate bleeding during hospitalisation.
§Appropriate use of C/P at discharge: patients not eligible for P, discharged with C or patients eligible for P, discharged with P.
C, clopidogrel; MIs, myocardial infarction; P, prasugrel; PPCI, primary percutaneous coronary intervention; STEMI, ST elevation myocardial infarction; TIA, transient ischaemic attack.