Table 2

Summary of meta-regression of differences observed by each method

Mean difference compared to cardiac MR
Imaging modalityYear publishedLVEDV (mL) (95% CI)Overall p valueI2
p value
LVESV (mL) (95% CI)Overall p valueI2
p value
LVEF (%) (95% CI)Overall p valueI2
p value
2D-echocardiography
Volumes N=1579, LVEF N=1683
Overall−33.26 (−43.42 to −20.65)<0.000187% p<0.0001−16.20 (−21.36 to −11.04)<0.000173% <0.0001−0.66 (−2.14 to 0.82)0.3872% <0.0001
<2005−23.23 (−43.86 to −2.59)0.0377% p<0.0001−12.15 (−18.55 to --5.75)0.00020% 0.05−2.11 (−4.48 to 0.26)0.083% 0.40
2005–2009−33.49 (−46.88 to −20.09)<0.000190% p<0.0001−17.73 (−25.11 to −10.36)<0.000181% <0.0001−0.26 (−2.32 to 1.81)0.8181% <0.0001
>2009−46.46 (−72.27 to −20.65)0.000483% p<0.0001−18.73 (−29.46 to −8.01)0.000658% 0.05−1.14 (−3.03 to 0.21)0.090% 0.67
2D-echocardiography with contrast
Volumes and LVEF N=283
Overall*−18.05 (−6.39 to −9.7)<0.00010% p=0.45−7.84 (−14.46 to −1.22)0.020% p=0.99−1.03 (−3.38 to 1.35)0.390% p=0.61
3D-echocardiography
Volumes N=1159, LVEF N=1104
Overall−14.16 (−18.66 to −9.66)<0.000123% p=0.12−6.49 (−9.91 to −3.07)0.00020% p=0.960.13 (−0.91 to 1.16)0.810% p=1.00
<2005−15.14 (−25.17 to −5.12)0.0030% p=0.49−6.38 (−13.36 to 0.60)0.070% p=0.910.25 (−2.09 to 2.59)0.830% p=1.00
2005–2009−13.32 (−18.64 to −8.01)<0.000143% p=0.01−6.27 (−10.41 to −2.13)0.0030% p=0.720.02 (−1.20 to 1.23)0.980% p=0.99
>2009−18.95 (−34.54 to −3.36)0.020% p=0.86−8.77 (−21.00 to 3.47)0.160% p=0.840.89 (−2.93 to 4.70)0.659% p=0.33
Multidetector CT
Volumes N=790, LVEF N=780
Overall−1.16 (−4.14 to 1.83)0.450% p=0.90−0.11 (−2.40 to 2.18)0.930% p=0.960.86 (−0.21 to 1.94)0.120% p=0.55
2007–20095.21 (−2.13 to 12.54)0.160% p=0.742.59 (−1.19 to 6.36)0.180% p=0.930.45 (−1.27 to 2.17)0.510% p=0.94
>2009−2.41 (−5.68 to 0.85)0.150% p=0.99−1.68 (−4.56 to 1.21)0.250% p=0.971.13 (−0.25 to 2.50)0.114% p=0.40
  • Values are mean (95% CI).

  • *Insufficient number of studies for subgroup analysis.

  • LVEDV, Left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume.