TableĀ 2

Summary of the results from the QUADAS-2 tool for each of the included papers

Risk of biasApplicability concerns
StudyPatient selectionIndex testReference standardFlow and timingPatient selectionIndex testReference standard
Wiesel et al11Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Stergiou et al12Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Wiesel et al13Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Marazzi et al14Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Wiesel et al15Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Kearley et al16Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
Wiesel et al17Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
  • Embedded Image, low risk; Embedded Image, high risk; Embedded Image, unclear risk.