HRs (95% CI) for incident coronary events by tertiles of cathepsin D in the MDC-CC
| First tertile | Second tertile | Third tertile | p for trend | |
|---|---|---|---|---|
| Cathepsin D (AU) | <147 | 147–200 | >200 | |
| Coronary events (n) | 107 | 124 | 153 | |
| Coronary events, HR (95% CI)* | 1 | 1.22 (0.94 to 1.58) | 1.62 (1.27 to 2.08) | 0.0001 |
| Coronary events, HR (95% CI)† | 1 | 1.11 (0.85 to 1.45) | 1.42 (1.09 to 1.85) | 0.009 |
| Coronary events, HR (95% CI)‡ | 1 | 1.09 (0.83 to 1.43) | 1.34 (1.02 to 1.75) | 0.033 |
| Coronary events, HR (95% CI)§ | 1 | 1.11 (0.84 to 1.46) | 1.28 (0.97 to 1.69) | 0.074 |
| Coronary events, HR (95% CI)¶ | 1 | 1.09 (0.83 to 1.44) | 1.22 (0.92 to 1.61) | 0.17 |
*Non-adjusted.
†Adjusted for age, sex, LDL/HDL ratio, triglycerides, BMI and hypertension.
‡Adjusted for age, sex, LDL/HDL ratio, triglycerides, BMI, hypertension and glucose.
§Adjusted for age, sex, LDL/HDL ratio, triglycerides, BMI, hypertension and current smoking.
¶Adjusted for age, sex, LDL/HDL ratio, triglycerides, BMI, hypertension, glucose and current smoking.
AU, arbitrary units; BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MDC-CC, Malmö Diet and Cancer Cardiovascular Cohort.