Baseline characteristics
| Variable | eGFR≥90 n=5251 | eGFR 60–89 n=18 240 | eGFR 30–59 n=19 160 | eGFR 15–29 n=4252 | eGFR<15 n=813 | p Value |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age (years) (n=47 716) | 60 (51–66) | 74 (65–81) | 81 (74–86) | 83 (78–88) | 81 (73–87) | <0.001 |
| Female (n=47 716) | 27% | 35% | 44% | 50% | 42% | <0.001 |
| Risk factors | ||||||
| Hypertension (n=47 702) | 36% | 45% | 52% | 57% | 62% | <0.001 |
| Diabetes mellitus (n=47 704) | 21% | 21% | 26% | 35% | 36% | <0.001 |
| Smoking (n=47 711) | 24% | 11% | 6% | 5% | 8% | <0.001 |
| Alcohol overconsumption (n=47 703) | 6% | 3% | 1% | 1% | 1% | <0.001 |
| Heart disease | ||||||
| Previous myocardial infarction (n=18 285) | 24% | 29% | 37% | 41% | 37% | <0.001 |
| Ischaemic heart disease (n=47 698) | 33% | 41% | 50% | 56% | 54% | <0.001 |
| Atrial fibrillation/flutter (n=47 702) | 32% | 48% | 54% | 52% | 42% | <0.001 |
| Valvular heart disease (n=47 699) | 14% | 19% | 23% | 24% | 19% | <0.001 |
| Dilated cardiomyopathy (n=47 698) | 22% | 12% | 7% | 5% | 5% | <0.001 |
| Hypertrophic cardiomyopathy (n=29 648) | 2% | 2% | 2% | 2% | 2% | 0.672 |
| Comorbidity | ||||||
| Previous stroke (n=18 281) | 7% | 12% | 15% | 17% | 19% | <0.001 |
| Pulmonary disease (n=47 704) | 17% | 17% | 18% | 19% | 18% | 0.004 |
| Previous procedures | ||||||
| Revascularisation (n=47 675) | 23% | 24% | 25% | 23% | 23% | 0.113 |
| Valve intervention (n=47 703) | 5% | 5% | 6% | 6% | 3% | 0.372 |
| CRT (n=47 700) | 2% | 2% | 2% | 2% | 2% | 0.710 |
| Characterisation of heart failure | ||||||
| Hospitalisation at inclusion (n=47 713) | 48% | 61% | 70% | 83% | 90% | <0.001 |
| New heart failure (n=18 279) | 53% | 43% | 29% | 20% | 20% | <0.001 |
| Heart failure >6 month (n=47 254) | 32% | 40% | 55% | 65% | 59% | <0.001 |
| NYHA class (n=32 848) | ||||||
| NYHA I (n=3753) | 20% | 14% | 8% | 5% | 6% | <0.001 |
| NYHA II (n=14 844) | 51% | 50% | 42% | 32% | 28% | <0.001 |
| NYHA III (n=12 582) | 27% | 33% | 44% | 50% | 42% | <0.001 |
| NYHA IV (n=1669) | 2% | 3% | 6% | 13% | 24% | <0.001 |
| Left ventricular ejection fraction (n=41 369) | ||||||
| >50% (n=9166) | 15% | 20% | 25% | 28% | 26% | <0.001 |
| 40–49% (n=8566) | 20% | 21% | 20% | 20% | 21% | 0.508 |
| 30–39% (n=11 323) | 29% | 28% | 26% | 25% | 27% | <0.001 |
| <30% (n=12 314) | 36% | 31% | 28% | 28% | 26% | <0.001 |
Values are proportion or median and IQR.
CRT, cardiac resynchronisation therapy; NYHA, New York Heart Association.