Table 2

Diagnostic yield and therapeutic consequences of additional testing in ‘idiopathic’ dilated cardiomyopathy

Diagnostic testDiagnostic yieldTherapeutic consequences
Cardiac MRITwo patients diagnosed with non-compaction cardiomyopathyOral anticoagulation initiated and ICDs implanted
MRI with gadolinium contrastTwo patients diagnosed with cardiomyopathy in association with systemic inflammatory diseaseAppropriate immunosuppressant therapy initiated
Right-sided cardiac catheterisationNoneNo direct therapeutic consequences. Haemodynamic data can be used to optimise diuretic treatment
Endomyocardial biopsyTwo patients diagnosed with cardiac sarcoidosis* and ATTR-amyloidosis, respectivelyPatient with sarcoidosis treated with prednisone
Exercise test with measurement of peak oxygen consumptionNoneVentricular arrhythmia prompted ICD implantation in two patients. Peak oxygen consumption one of several parameters used in stratification for heart transplantation
Twenty-four-hour ECGNoneNo direct consequences. Detection of non-sustained ventricular tachycardia strengthens the case for ICD implantation
Genetic screeningTen patients diagnosed with possible disease-causing mutationsFinding prompted ICD implantation in one patient. Allowed for family screening
  • *This patient was also diagnosed on cardiac MRI with late gadolinium enhancement.

  • ICD, implantable cardioverter-defibrillator.