Plasma concentrations of angiogenesis-related biomarkers and their correlation with calibrated integrated backscatter values in 29 men and 11 women with coronary artery disease
| Variable | Mean±SD or median (IQR) (n=33–40) | r | p Value |
|---|---|---|---|
| VEGF-A (pg/mL) | 22 (13–33)* | −0.17† | 0.34† |
| sVEGFR-1 (pg/mL) | 90 (64–131)* | 0.44† | 0.01† |
| sVEGFR-2 (ng/mL) | 6.5±1.1 | 0.07 | 0.70 |
| Angiopoietin-1 (ng/mL) | 3.5 (2.0–4.5)* | −0.30† | 0.09† |
| Angiopoietin-2 (ng/mL) | 1.4 (1.2–1.9)* | 0.29† | 0.10† |
| Tie-1 (ng/mL) | 36±9 | 0.04 | 0.82 |
| Tie-2 (ng/mL) | 15±4 | 0.14 | 0.44 |
| Fibroblast growth factor basic (pg/mL) | 6.8±2.9 | −0.03 | 0.85 |
| Endostatin (ng/mL) | 99±44 | 0.16 | 0.38 |
| Placental growth factor (pg/mL) | 11±4 | 0.32 | 0.07 |
| Hepatocyte growth factor (pg/mL) | 850 (622–969)* | 0.26† | 0.14† |
| Nε-(carboxymethyl)lysine (μmol/L) | 1.8±0.6 | 0.12 | 0.46 |
| LMWF (AU/mL) | 2.3 (1.5–3.3)* | 0.08† | 0.61† |
| sRAGE | 527 (456–937)* | 0.53† | 0.002† |
*Median value and IQR given non-parametric distribution.
†Values derived from log-transformed data; n=40 for Nε-(carboxymethyl)lysine and LMWF levels, and n=33 for all other angiogenesis-related biomarkers.
LMWF, low-molecular-weight fluorophore; sRAGE, soluble receptor for advanced glycation end products; VEGF, vascular endothelial growth factor; sVEGFR, soluble VEGF receptor.