Table 4

Multivariate hazard model showing adjusted HRs and corresponding 95% CI for calibrated Framingham risk factors including AST/ALT ratio

Adjusted HR (95% CI)
Risk factorsMenWomen
Age (years)*53.33 (30.64 to 92.83)†158.65 (76.38 to 329.55)†
Total cholesterol (mmol/L)*1.05 (0.63 to 1.77)1.10 (0.58 to 2.09)
HDL cholesterol (mmol/L)*0.53 (0.37 to 0.76)†0.43 (0.28 to 0.66)†
Systolic blood pressure if treated (mm  Hg)*2.07 (1.02 to 4.43)†2.62 (1.06 to 6.52)†
Systolic blood pressure if no treatment (mm  Hg)*2.05 (1.01 to 4.36)†2.67 (1.08 to 6.58)†
Smoking
 NoRefRef
 Yes1.48 (1.20 to 1.83)†2.09 (1.61 to 2.70)†
Diabetes
 NoRefRef
 Yes1.35 (1.02 to 1.77)†1.69 (1.16 to 2.46)†
 AST/ALT ratio*1.37 (1.05 to 1.79)†1.06 (0.78 to 1.43)
  • *Variable log transformed.

  • †p<0.05.

  • ALT, alanine transaminase; AST, aspartate transaminase; HDL, high-density lipoprotein.