Table 5

Multivariate hazard model showing adjusted HRs and 95% CI for calibrated QRISK2 risk factors including AST/ALT ratio

Adjusted HR (95% CI)
Risk factorsMenWomen
Age (years)*63.80 (34.65–117.48)†112.76 (50.92–249.70)†
Total cholesterol/HDL cholesterol ratio*1.33 (1.01–1.92)†2.05 (1.33–3.16)†
Systolic blood pressure (mm  Hg)*1.84 (1.04–3.96)†2.80 (1.12–7.02)†
Body mass index (kg/m2)*2.84 (0.84–9.60)0.62 (0.16–2.33)
Blood pressure treatment
 NoRefRef
 Yes0.89 (0.71–1.12)1.08 (0.83–1.39)
Smoking
 NoRefRef
 Yes1.51 (1.21–1.89)†1.97 (1.50–2.59)†
Diabetes
 NoRefRef
 Yes1.36 (1.03–1.79)†1.84 (1.27–2.66)†
Chronic kidney disease
 NoRefRef
 Yes1.97 (1.02–3.99)†2.85 (1.05–7.74)†
Atrial fibrillation
 NoRefRef
 Yes1.91 (1.32–2.76)†2.32 (1.49–3.62)†
Rheumatoid arthritis
 NoRefRef
 Yes1.50 (0.74–3.02)1.47 (0.80–2.69)
Townsend fifths
 1st—least deprivedRefRef
 2nd1.12 (0.86–1.46)0.96 (0.69–1.32)
 3rd1.37 (1.04–1.79)†0.86 (0.61–1.21)
 4th1.33 (1.02–1.74)†1.16 (0.84–1.60)
 5th—most deprived1.12 (0.77–1.62)1.28 (0.88–1.86)
Ethnicity
 CaucasianRefRef
 Non-Caucasian0.75 (0.56–0.99)0.86 (0.61–1.21)
 AST/ALT Ratio*1.40 (1.04–1.89)†0.97 (0.70–1.35)
  • *Variable log transformed.

  • †p<0.05.

  • ALT, alanine transaminase; AST, aspartate transaminase; HDL, high-density lipoprotein.