Guilt by association indicators among family members
| Regarding family members | ||
|---|---|---|
| Situation | Recommendation | Comments |
| Patient affected by TAA (syndromic—Marfan, Ehler-Danlos, Loeys-Dietz) | Image and genotype all first-order family members (ECHO±CT scan) | Autosomal dominant inheritance (with incomplete penetrance) |
| Patient affected by TAA (non-syndromic) | Image all first-order family members (ECHO±CT scan) | 21% likelihood of family member with known TAA (additional affected family members likely to be identified by imaging) |
| Patient affected by bicuspid aortic valve | Image all first-order family members for bicuspid valve, TAA | 8% likelihood of family member being affected |
ECHO, echocardiogram; TAA, thoracic aortic aneurysm.