TableĀ 6

Performance of MCE risk models including traditional risk factors with and without hsCRP

C-index(95% CI)p ValueNRI(95% CI)IDI(95% CI)p Value
Basic model0.57(0.43 to 0.71)
Basic model+baseline hsCRP and 1-year changes0.60(0.41 to 0.79)<0.050.24(0.13 to 0.38)0.03(0 to 0.07)0.07
  • Basic model: age, sex, heart rate, white cell count, tobacco and treatment group.

  • hsCRP, high-sensitivity C reactive protein; IDI, integrated discrimination improvement; MCE, major cardiovascular event; NRI, net reclassification improvement.