Study | Technological intervention | Study population | Medications | Design | Study size (mean age) | Duration | Main adherence measure | Main findings |
---|---|---|---|---|---|---|---|---|
Quilici et al34 | Mobile-phone—daily personalised SMS reminders | Patients who had undergone coronary stenting for ACS with good in-hospital aspirin response defined by AA-Ag lower than 30% | Aspirin | RCT | 546 patients (intervention: 64±10; control 64±14) | 1 month | Self-reporting and AA-Ag testing | Improved medication adherence with daily SMS reminders—self-reported aspirin non-adherence: 3.6% (SMS intervention) vs 6.4% (standard care) p=0.02; AA-Ag testing: 5.2% SMS intervention) vs 11.2% (standard care); p=0.01 |
Rinfret et al38 | Telephone contact by nurses—4 sessions (<7 days, 1, 6 and 9 months) after stent implantation | Patients who had undergone drug-eluting stent implantation | Aspirin and clopidogrel | RCT | 300 patients (64±10) | 12 months | Proportion of days covered with aspirin and clopidogrel as assessed by pharmacy refill data | Significant improvement in adherence with four telephone calls—median scores for aspirin (99.2% vs 90.2%; intervention vs standard care respectively) and clopidogrel (99.3% vs 91.5%); p<0.0001 for aspirin and clopidogrel |
Ho et al39 | Multifaceted—including voice messaging (educational and medication refill reminder calls) | Patients admitted with ACS | Clopidogrel, β-blockers, statins, ACEI/ARB | RCT | 253 patients (intervention: 63.8±9.25; control: 64.0±8.57) | 12 months | Proportion of patients adherent to medication regimens based on mean proportion of days covered greater than 0.80 using pharmacy refill data | Increased adherence—89.3% vs 73.9% of patients were adherent (intervention vs usual care); p=0.003 |
AA-Ag: arachidonic acid induced platelet aggregation; ACEI: angiotensin-converting-enzyme inhibitor; ACS: acute coronary syndromes; ARB: angiotensin receptor blocker; RCT: randomised controlled trial; SMS: short messaging service.