Table 1

Characteristics of included studies

Study	Journal	Year	Number of patients	First generation	Second generation	Short-term follow-up (≤12 months)	Long-term follow-up (>12 months)	Primary end point	MACE/TVF definition	Clinical setting	Minimal DAPT duration (ADP receptor/ P2Y12 inhibitor)	Protocol defined follow-up angiography
APPENDIX-AMI13 14	PLoS ONE	2013	977	SES Cypher	EES Xience V	12 months*	24 months	MACE	Cardiac mortality, MI, TVR	Stable/ACS	12 months	No
BASKET-PROVE15	NEJM	2010	1549	SES Cypher	EES Xience V	n.r.	24 months	MACE	Mortality, MI, TVR	Stable/ACS	12 months	No
CATOS16	Circulation Journal	2012	160	SES Cypher	ZES Endeavor	12 months	n.r.	In-segment binary restenosis rate at 9 months angiographic follow-up	Cardiac mortality, MI, TVR	CTO	12 months	Yes
CIBELES17	Circulation Cardiovascular Interventions	2013	207	SES Cypher	EES Xience V	12 months	n.r.	In-stent late loss at 9 months angiographic follow-up	Mortality, MI, TVR	TCO	12 months	Yes
COMPARE18–20	Lancet JACC	2010 2011	1800	PES Taxus Liberte	EES Xience V	12 months	24, 36 months	MACE	Mortality, MI, TVR	Stable/ACS	12 months	No
ENDEAVOR III21 22	JACC JACC Cardiovascular Interventions	2006 2011	436	SES Cypher	ZES Endeavor	9 months	60 months	In-segment late lumen loss at 8 months angiographic follow-up	Mortality, MI, TLR	Stable/ACS	3 months	Yes
ENDEAVOR IV23 24	JACC JACC Cardiovascular Interventions	2010 2013	1548	PES Taxus Express	ZES Endeavor	12 months	60 months	TVF at 9 months	Mortality, MI, TLR	Stable/ACS	6 months	Yes
ESSENCE-Diabetes25	Circulation	2011	300	SES Cypher	EES Xience V	12 months	n.r.	In-segment late lumen loss at 8 months angiographic follow-up	Mortality, MI, TLR	Stable/ACS	12 months	Yes
EXCELLENT26	JACC	2011	1428	SES Cypher	EES Xience V or Promus	12 months	n.r.	In-segment late lumen loss at 9 months angiographic follow-up	Cardiac mortality, MI, TLR	Stable/ACS	6 months	Yes
EXECUTIVE27	JACC Cardiovascular Interventions	2013	200	PES Taxus Liberte	EES Xience V	12 months	n.r.	In-segment late lumen loss at 9 months angiographic follow-up	Mortality, MI, TVR	Stable/ACS	6 months	Yes
ISAR-TEST-228 29	EHJ JACC	2009 2010	674	SES Cypher	ZES Endeavor	12 months	24 months	binary angiographic restenosis at 6–8-month follow-up angiography	Mortality, MI, TLR	Stable/ACS	12 months	Yes
KOMER30	EuroIntervention	2011	611	SES Cypher and PES Taxus Express	ZES Endeavor	12 months	18 months	MACE	Cardiac mortality, MI, TLR	STEMI	12 months	Yes
LONG-DES III31	JACC	2011	450	SES Cypher	EES Xience V or Promus	12 months	n.r.	In-segment late lumen loss at 9 months angiographic follow-up	Mortality, MI, TVR	Stable/ACS	12 months	Yes
LONG-DES IV32	Circulation Cardiovascular Interventions	2012	500	SES Cypher	ZES Resolute	12 months	n.r.	In-segment late lumen loss at 9 months angiographic follow-up	Mortality, MI, TVR	Stable/ACS	12 months	Yes
Naples-Diabetes33	Circulation Cardiovascular Interventions	2011	226	SES Cypher and PES Taxus Liberte	ZES Endeavor	In-hospital; 12 months	36 months	MACE	Mortality, MI, TVR	Stable/ACS	6 months	No
PRISON III34	EuroIntervention	2013	304	SES Cypher	ZES Resolute or ZES Endeavor	12 months	n.r.	In-segment late lumen loss at 8 months angiographic follow-up	Mortality, MI, TLR	TCO	12 months	Yes
R-CHINA RCT35	JACC Cardiovascular Interventions	2013	400	PES Taxus Liberte	ZES Resolute	12 months	n.r.	In-stent late lumen loss at 9 months angiographic follow-up	Mortality, MI, TLR	Stable/ACS	6 months	Yes
RESET36	Circulation	2012	3197	SES Cypher	EES Xience V	12 months	n.r.	TLR at 12 months; composite of all-cause death and MI at 36 months	Cardiac mortality, MI, TLR	Stable/ACS	3 months	No
Sakakibara et al37	Circulation Journal	2012	100	SES Cypher	EES Xience V	12 months	n.r.	binary angiographic restenosis at 8 month follow-up angiography	Mortality, MI, TLR	Stable	12 months	Yes
Sawada et al38	International Journal of Cardiology	2012	35	SES Cypher	EES Xience V or Promus	7 months	n.r.	Neointimal thickness and ST	n.a.	STEMI	7 months	Yes
SEA-SIDE39	JACC Cardiovascular Interventions	2011	150	SES Cypher	EES Xience V	n.r.	18 months	Occurrence of any trouble in the side-branch (SB) management	Mortality, MI, TVR	Stable/ACS	12 months	No
SEZE40	Chinese Medical Journal	2012	122	SES Cypher	ZES Endeavor	12 months	n.r.	In-stent late lumen loss at 9 months angiographic follow-up	Cardiac mortality, MI, TVR	STEMI	12 months	Yes
Song et al41	JACC	2012	1114	SES Cypher	EES Xience V	12 months	n.r.	In-segment late lumen loss at 9 months angiographic follow-up	Mortality, MI, TVR	Stable/ACS	6 months	Yes
SORT OUT III42 43	Lancet JACC Cardiovascular Interventions	2010 2013	2332	SES Cypher	ZES Endeavor	9 months	36 months	MACE	Cardiac mortality, MI, TVR	Stable/ACS	12 months	No
SORT OUT IV44 45	Circulation JACC	2012 2012	2774	SES Cypher	EES Xience V or Promus	9 months	24, 36 [ref-tctmd] months	MACE	Cardiac mortality, MI, TVR, def. ST	Stable/ACS	12 months	No
SPIRIT II46 47	EuroIntervention EuroIntervention	2007 2012	300	PES Taxus Liberte or PES Taxus Express	EES Xience V	12 months	60 months	In-stent late lumen loss at 6 months angiographic follow-up	Cardiac mortality, MI, TLR	Stable/ACS	12 months	Yes
SPIRIT III48 49	JAMA The American Journal of Cardiology	2008 2011	1001	PES Taxus Express	EES Xience V	12 months	36, 60 [ref stone ppt] months	In-stent late lumen loss at 8 months angiographic follow-up	Cardiac mortality, MI, TLR	Stable/ACS	6 months	Yes
SPIRIT IV50 51	NEJM JACC	2010 2011	3687	PES Taxus Express	EES Xience V	12 months	24 months	Composite of cardiac death, target vessel MI and TLR	Cardiac mortality, MI, TLR	Stable/ACS	12 months	No
SPIRIT V Diabetic Study52	American Heart Journal	2012	324	PES Taxus Liberte	EES Xience V	12 months	n.r.	In-stent late lumen loss at 9 months angiographic follow-up	Mortality, MI, TVR	Stable/ACS	6 months	Yes
Wang et al53	JACC abstracts	2011	875	SES Cypher	ZES Endeavor	6 months	n.r.	MACE	Cardiac mortality, MI, TLR	STEMI	n.r.	No
XAMI54	JACC	2012	625	SES Cypher	EES Xience V	12 months	n.r.	MACE	Cardiac mortality, MI, TVR	STEMI	12 months	No
ZEST55	JACC	2010	2645	SES Cypher or PES Taxus Liberte	ZES Endeavor	12 months	n.r.	MACE	Mortality, MI, TVR	Stable/ACS	12 months	Yes
ZEST-AMI56 57	The American Journal of Cardiology	2009	328	SES Cypher or PES Taxus Liberte	ZES Endeavor	12 months	n.r.	MACE	Mortality, MI, TVR	STEMI	12 months	Yes

ACS, acute coronary syndrome; DAPT, dual antiplatelet therapy; EES, everolimus-eluting stent; MACE, major adverse cardiovascular events; MI, myocardial infarction; PES, paclitaxel-eluting stent; SES, sirolimus-eluting stent; STEMI, ST elevation myocardial infarction; TLR, target lesion revascularisation; TVR, target vessel revascularisation; ZES, zotarolimus-eluting stent.