0 h* | 6 h | 24 h | 48 h | 72 h | 168 h | ANOVA | |
---|---|---|---|---|---|---|---|
Angiography | |||||||
CD34+ | 2.45 (1.54–3.21) | 2.17 (1.59–2.94) | 1.63 (1.37–2.28) | 1.74 (1.31–2.75) | 2.17 (1.35–3.13) | 1.88 (1.66–2.79) | 0.14 |
CD34+VEGFR-2+ | 0.27 (0.09–0.71) | 0.36 (0.08–1.50) | 0.13 (0.03–0.41) | 0.21 (0.09–0.48) | 0.06 (0.02–0.40) | 0.13 (0.07–0.87) | 0.22 |
CD34+VEGFR-2+CD133+ | 0.04 (0.01–0.55) | 0.10 (0.03–0.44) | 0.10 (0.0–0.36) | 0.05 (0.01–0.19) | 0.03 (0.0–0.49) | 0.03 (0.0–0.24) | 0.44 |
CD34+CD45+ | 1.77 (0.90–2.48) | 1.11 (0.94–1.87) | 1.31 (0.97–1.96) | 1.36 (1.08–1.69) | 1.46 (0.86–1.96) | 1.36 (0.81–1.67) | 0.73 |
CD34+CD45− | 0.71 (0.31–1.20) | 0.60 (0.31–1.70) | 0.39 (0.27–0.82) | 0.41 (0.26–0.67) | 0.52 (0.21–1.4) | 0.61 (0.21–1.1) | 0.43 |
CD34+CD45−VEGFR-2+ | 0.06 (0.01–0.31) | 0.08 (0.02–0.31) | 0.02 (0.002–0.17) | 0.06 (0.0–0.13) | 0.02 (0.0–0.29) | 0.05 (0.01–0.11) | 0.33 |
CD14+Tie 2+VEGFR-2+† | 3.0 (1.8–11.1) | 2.8 (1.2–14.3) | 2.0 (1.3–10.8) | 2.5 (0.70–6.37) | 3.2 (2.1–12.6) | 2.7 (0.97–8.61) | 0.39 |
PCI | |||||||
CD34+ | 2.58 (1.70–3.36) | 2.94 (2.07–4.05) | 2.36 (1.74–3.52) | 2.42 (1.75–3.29) | 2.20 (1.60–2.64) | 2.49 (1.36–3.25) | 0.08 |
CD34+VEGFR-2+ | 0.13 (0.02–0.52) | 0.18 (0.05–0.85) | 0.17 (0.03–0.47) | 0.22 (0.02–0.56) | 0.12 (0.05–0.41) | 0.11 (0.03–0.38) | 0.3 |
CD34+VEGFR-2+CD133+ | 0.05 (0.0–0.92) | 0.14 (0.0–1.3) | 0.04 (0.0–0.77) | 0.08 (0.0–0.75) | 0.03 (0.0–0.74) | 0.04 (0.0–0.72) | 0.27 |
CD34+CD45+ | 1.41 (0.84–2.14) | 1.69 (0.97–2.34) | 1.79 (1.12–2.69) | 1.64 (1.28–2.11) | 1.72 (0.96–2.07) | 1.63 (0.96–2.34) | 0.6 |
CD34+CD45− | 0.93 (0.43–1.49) | 1.51 (0.96–2.15)‡ | 0.71 (0.40–0.98) | 0.70 (0.46–1.14) | 0.52 (0.21–0.73) | 0.76 (0.36–1.05) | <0.0001 |
CD34+CD45−VEGFR-2+ | 0.09 (0.0–0.32) | 0.17 (0.02–0.52) | 0.09 (0.01–0.37) | 0.06 (0.0–0.36) | 0.05 (0.0–0.19) | 0.04 (0.02–0.16) | 0.1 |
CD14+Tie 2+VEGFR-2+ | 3.1 (0.98–7.1) | 4.3 (2.4–13) | 4.1 (1.8–11) | 3.1 (0.30–13) | 3.1 (0.55–6.1) | 2.1 (1.1–9.3) | 0.68 |
Concentrations are the median and IQR×106/L of blood. Statistical analyses are performed using repeated measures ANOVA (Friedman's test) with Dunn's Multiple comparison post test. Comparisons between time points are made using a Wilcoxon test.
*Between group comparisons at baseline were made for each variable using a Mann–Whitney test.
†n=10.
‡p=0.01 for baseline compared to time point.
ANOVA, analysis of variance; CD, cluster of differentiation; CRP, C reactive protein; PCI, percutaneous coronary intervention; VEGFR-2, vascular endothelial growth factor receptor-2.