Predictive value of severe ischaemia (levels 4 and 5) by MCG, ECG and FRS
| Test | κ Coefficient (95% CI) | p Value | Accuracy | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|
| (A) Model 1 (adjusted by FFR≤0.8) | |||||||
| All patients | |||||||
| MCG (H vs B/L) | 0.42 (0.22 to 0.62) | – | 79.0 (74.9 to 83.1) | 48.1 (38.5 to 57.8) | 90.4 (87.0 to 93.9) | 65.0 (54.3 to 75.7) | 82.5 (78.3 to 86.7) |
| ECG (P vs N) | 0.12 (−0.08 to 0.33) | 0.020 | 69.0 (64.4 to 73.6) | 25.9 (17.5 to 34.4) | 84.9 (80.7 to 89.1) | 38.9 (27.4 to 50.4) | 75.6 (70.9 to 80.4) |
| FRS (H vs I/L) | 0.16 (0.02 to 0.31) | 0.024 | 54.0 (49.0 to 59.0) | 77.8 (69.8 to 85.8) | 45.2 (39.4 to 51.0) | 34.4 (28.3 to 40.5) | 84.6 (78.8 to 90.4) |
| Male | |||||||
| MCG (H vs B/L) | 0.40 (0.16 to 0.64) | – | 76.5 (71.3 to 81.6) | 47.6 (36.7 to 58.5) | 89.4 (84.9 to 93.9) | 66.7 (54.3 to 78.8) | 79.2 (73.7 to 84.8) |
| ECG (P vs N) | 0.07 (−0.1 to 0.30) | 0.027 | 66.2 (60.4 to 71.9) | 19.0 (10.5 to 27.6) | 87.2 (82.4 to 92.1) | 40.0 (24.5 to 55.5) | 70.7 (64.7 to 76.7) |
| FRS (H vs I/L) | 0.05 (−0.08 to 0.18) | 0.001 | 41.2 (35.2 to 47.1) | 85.7 (78.1 to 93.4) | 21.3 (15.3 to 27.2) | 32.7 (26.4 to 39.1) | 76.9 (65.2 to 88.6) |
| Female | |||||||
| MCG (H vs B/L) | 0.45 (0.05 to 0.86) | – | 84.4 (78.0 to 90.8) | 50.0 (29.6 to 70.4) | 92.3 (87.1 to 97.5) | 60.0 (38.1 to 81.9) | 88.9 (82.8 to 94.9) |
| ECG (P vs N) | 0.27 (−0.11 to 0.65) | 0.77 | 75.0 (67.3 to 82.7) | 50.0 (29.6 to 70.4) | 80.8 (73.0 to 88.5) | 37.5 (20.4 to 54.6) | 87.5 (80.7 to 94.3) |
| FRS (H vs I/L) | 0.38 (−0.02 to 0.79) | 0.94 | 81.3 (74.4 to 88.1) | 50.0 (29.6 to 70.4) | 88.5 (82.2 to 94.7) | 50.0 (29.6 to 70.4) | 88.5 (82.2 to 94.7) |
| (B) Model 2 (adjusted by FFR ≤0.75) | |||||||
| All patients | |||||||
| MCG (H vs B/L) | 0.32 (0.10 to 0.54) | – | 77.0 (72.8 to 81.2) | 43.5 (33.1 to 53.8) | 87.0 (83.2 to 90.8) | 50.0 (38.8 to 61.2) | 83.8 (79.6 to 87.9) |
| ECG (P vs N) | 0.05 (−0.15 to 0.26) | 0.066 | 69.0 (64.4 to 73.6) | 21.7 (13.1 to 30.3) | 83.1 (78.8 to 87.4) | 27.8 (17.2 to 38.3) | 78.0 (73.5 to 82.6) |
| FRS (H vs I/L) | 0.14 (0.01 to 0.28) | 0.24 | 52.0 (47.0 to 57.0) | 78.3 (69.7 to 86.9) | 44.2 (38.5 to 49.8) | 29.5 (23.7 to 35.5) | 87.2 (81.8 to 92.5) |
| Male | |||||||
| MCG (H vs B/L) | 0.38 (0.13 to 0.62) | – | 76.5 (71.3 to 81.6) | 47.4 (35.9 to 58.8) | 87.8 (83.1 to 92.4) | 60.0 (47.4 to 72.6) | 81.1 (75.8 to 86.5) |
| ECG (P vs N) | 0.02 (−0.21 to 0.24) | 0.014 | 66.2 (60.4 to 71.9) | 15.8 (7.4 to 24.2) | 85.7 (80.7 to 90.7) | 30.0 (15.5 to 44.5) | 72.4 (66.5 to 78.3) |
| FRS (H vs I/L) | 0.03 (−0.10 to 0.16) | 0.002 | 38.2 (32.3 to 44.1) | 84.2 (75.8 to 92.6) | 20.4 (14.7 to 26.2) | 29.1 (23.0 to 35.2) | 76.9 (65.2 to 88.6) |
| Female | |||||||
| MCG (H vs B/L) | 0.10 (−0.30 to 0.50) | – | 78.1 (70.8 to 85.4) | 25.0 (3.3 to 46.7) | 85.7 (79.1 to 92.3) | 20.0 (2.1 to 37.9) | 88.9 (82.8 to 94.9) |
| ECG (P vs N) | 0.20 (−0.17 to 0.57) | 0.90 | 75.0 (67.3 to 82.7) | 50.0 (25.0 to 75.0) | 78.6 (70.8 to 86.3) | 25.0 (9.7 to 40.3) | 91.7 (86.0 to 97.3) |
| FRS (H vs I/L) | 0.29 (−0.13 to 0.72) | 0.75 | 81.3 (74.4 to 88.1) | 50.0 (29.6 to 70.4) | 88.5 (82.2 to 94.7) | 50.0 (29.6 to 70.4) | 92.3 (87.1 to 97.5) |
FRS, Framingham Risk Sore; H vs B/L, high versus borderline/low; H vs I/L, high versus intermediate/low; MCG, multifunction cardioGram; NPV, negative predictive value; PPV, positive predictive value; P vs N, positive versus negative.