Table 1

General characteristics of included studies

Study (reference)	Sample size (N)		Definition of CIN	Time of definition	Events (n)		Renal function defining inclusion or exclusion
Study (reference)	Statin	Control	Definition of CIN	Time of definition	Statin	Control	Renal function defining inclusion or exclusion
Acikel et al21	80	80	Increase in S Cr or serum Cystatin C or GFR	Within 48 h	0	1	Exclusion: CRF requiring dialysis and/or mod-severe decrease in GFR <60 mL/min/1.73 m²
Han et al13	1498	1500	S Cr ≥0.5 mg/dL or 25% above baseline	Within 72 h	34	58	Inclusion: Stage 2 or stage 3 CKD Exclusion: Stage 0,1,4 or 5 CKD
Jo et al26	118	118	Increase of either ≥25% or 0.5 mg/dL in S Cr	Within 48 h	3	4	Inclusion: Cr.Cl <60 mL/min or baseline S Cr ≥1.1 mg/dL
Leoncini et al¹⁴	252	252	S Cr ≥0.5 mg/dL or ≥25% above baseline	Within 72 h	17	38	Exclusion: ARF or ESRD requiring dialysis or S Cr ≥3 mg/dL
Li et al27	78	83	S Cr >0.5 mg/dL or 25% above baseline	Within 24 h	2	13	Exclusion: h/o renal dysfunction, patient on dialysis treatment
Ozhan et al25	60	70	Increase in S Cr >0.5 mg/dL or >25% from baseline	Within 48 h	2	7	Exclusion: (e)GFR <70 mL/min or pre-procedural S Cr >1.5 mg/dL
Patti et al24	120	121	Increase in S Cr ≥0.5 mg/dL or 25% from baseline	Within 48 h	6	16	Exclusion: Renal failure with S Cr >3 mg/dL
Quintavalle et al23	202	208	Increase >10% of S Cystatin C level	Within 24 h	9	37	Inclusion: Estimated GFR <60 mL/min/1.73 m². Patients with dialysis were excluded
Toso et al22	151	152	Increase of S Cr ≥0.5 mg/dL	Within 5 days	15	16	Inclusion: Baseline Cr Cl <60 mL/min (CGF)

ARF, acute renal failure; CIN, contrast-induced nephropathy; CKD, chronic kidney disease; Cr.Cl, creatinine clearance; GFR, glomerular filtration rate; S Cr, serum creatinine.