Table 3

Multivariable associations with cardiac mortality using time-updated model

Age-adjustedFully adjusted*
HR95% CIHR95% CIp Value
Peak flow rate (L/min)
 <4301.360.94 to 1.971.150.77 to 1.700.50
 430–<4901.210.83 to 1.771.100.74 to 1.64
 490–<5501.060.73 to 1.551.070.73 to 1.58
 ≥55011
Systolic blood pressure
 Per 10 mm Hg increase1.201.14 to 1.261.171.11 to 1.23<0.0001
Body mass index
 Per kg/m2 increase1.081.04 to 1.121.061.01 to 1.100.015
Smoking status
 Non-smoker110.018
 Ex-smoker1.180.80 to 1.730.980.66 to 1.45
 Current smoker1.741.21 to 2.511.500.99 to 2.25
Previous angina
 No110.001
 Yes2.051.41 to 2.971.931.31 to 2.83
Cholesterol
 Per mmol/L increase1.311.17 to 1.471.221.07 to 1.380.003
Fibrinogen (g/L)
 ≤3.5110.16
 >3.5–41.370.98 to 1.921.040.73 to 1.48
 >41.821.26 to 2.631.370.92 to 2.04
Factor VII (% of standard)
 Per 10 unit increase1.071.03 to 1.131.030.98 to 1.090.22
ECG
 Low risk11<0.0003
 High risk2.041.55 to 2.681.711.28 to 2.28
  • *Also adjusted for age, triglycerides, platelets, white blood cell count, red blood cell count, haemoglobin, packed cell volume, alcohol use, social class, factor V and factor VIII.

  • †Unadjusted HRs for peak flow rate are 3.18 (<430), 2.37 (430–<490) and 1.76 (490–<550) compared with ≥550 L/min.

  • ‡Trend test across groups.