Table 2

Baseline rates of bleeding by patient characteristics

Factor	Major bleed, N (%)	OR (CI)	p Value
Gender
Male	565 (1.4)	2.5 (2.3 to 2.9)	<0.001
Female	699 (3.6)	2.5 (2.3 to 2.9)	<0.001
Age
≤65	492 (1.6)	1.8 (1.6 to 2.0)	<0.001
≥66	772 (2.8)	1.8 (1.6 to 2.0)	<0.001
BMI
≤27	517 (2.7)	0.7 (0.6 to 0.8)	<0.001
>27	724 (1.9)	0.7 (0.6 to 0.8)	<0.001
HTN
No	185 (2.1)	1.0 (0.9 to 1.2)	0.72
Yes	1076 (2.2)	1.0 (0.9 to 1.2)	0.72
Dyslipidemia
No	252 (3.0)	0.7 (0.6 to 0.8)	<0.001
Yes	1009 (2.0)	0.7 (0.6 to 0.8)	<0.001
Diabetes
No	813 (2.2)	0.9 (0.8 to 1.0)	0.04
Yes	450 (2.0)	0.9 (0.8 to 1.0)	0.04
Prior MI
No	907 (2.4)	0.7 (0.6 to 0.8)	<0.001
Yes	357 (1.7)	0.7 (0.6 to 0.8)	<0.001
Prior CHF
No	1029 (2.0)	1.4 (1.2 to 1.6)	<0.001
Yes	232 (2.8)	1.4 (1.2 to 1.6)	<0.001
Prior PAD
No	1033 (2.0)	1.3 (1.2 to 1.6)	<0.001
Yes	228 (2.7)	1.3 (1.2 to 1.6)	<0.001
Current smoker
No	855 (2.1)	1.1 (1.0 to 1.3)	0.05
Yes	406 (2.3)	1.1 (1.0 to 1.3)	0.05
Kidney disease
No	1220 (2.1)	1.7 (1.2 to 2.4)	0.002
Yes	38 (3.6)	1.7 (1.2 to 2.4)	0.002
Lung disease
No	905 (1.9)	1.7 (1.5 to 1.9)	<0.001
Yes	356 (3.2)	1.7 (1.5 to 1.9)	<0.001
Prior PCI
No	899 (2.8)	0.47 (0.42 to 0.54)	<0.001
Yes	365 (1.4)	0.47 (0.42 to 0.54)	<0.001
Prior CABG
No	1077 (2.3)	0.64 (0.55 to 0.75)	<0.001
Yes	187 (1.5)	0.64 (0.55 to 0.75)	<0.001
Indication
STEMI	458 (5.8)	3.03 (2.6 to 3.4)	<0.001
Non-STEMI	534 (1.9)	3.03 (2.6 to 3.4)	<0.001
Closure
Compression	892 (2.4)	0.8 (0.7 to 1.0)	0.005
Device	118 (1.9)	0.8 (0.7 to 1.0)	0.005
Anticoagulant
Heparin	922 (2.4)	0.7 (0.6 to 0.7)	<0.001
Bivalirudin	340 (1.6)	0.7 (0.6 to 0.7)	<0.001

BMI, body mass index; CHF, congestive heart failure; CVD, cardiovascular disease; HTN, hypertension; MI, myocardial infarction; PAD, peripheral artery disease; PCI, percutaneous coronary intervention; STEMI, ST segment elevation myocardial infarction.