Table 1

Costs and clinical benefits of a 10-year FH service in the SHIP area. Costs with atorvastatin on and off patent compared in £'000s

Years since start of programme	1	2	3	4	5	6	7	8	9	10	Cumulative	Cumulative (%)
NICE cascade testing programme. Atorvastatin on patent
Numbers tested
Number tested—index cases	94	94	94	47	47	47	47	0	0	0	470	13.3
Number tested—relatives	615	615	615	308	308	308	308	0	0	0	3077	86.7
Total number tested	709	709	709	355	355	355	355	0	0	0	3547	100.0
Costs (in £’000s)
Drug therapy	£98	£197	£296	£345	£394	£443	£492	£492	£492	£492	£3741	67.7
Cascade testing	£182	£182	£182	£91	£91	£91	£91	£0	£0	£0	£910	16.5
Annual review meetings	£0	£23	£46	£69	£81	£92	£104	£109	£109	£109	£742	13.4
Specialist referrals	£27	£27	£27	£14	£14	£14	£14	£0	£0	£0	£135	2.4
Value of coronary events avoided	−£17	−£33	−£55	−£60	−£68	−£77	−£85	−£85	−£85	−£85	−£651	−11.8
Total recurrent costs per annum.	£290	£396	£496	£459	£511	£563	£615	£516	£516	£516	£4876
Total programme costs excluding clinical savings											£5528	100.0
NICE cascade testing programme. Atorvastatin off patent
Numbers tested
Number tested—index cases	94	94	94	47	47	47	47	0	0	0	470	13.3
Number tested—relatives	615	615	615	308	308	308	308	0	0	0	3077	86.7
Total number tested	709	709	709	355	355	355	355	0	0	0	3547	100.0
Costs (in £’000s)
Drug therapy	£46	£92	£138	£161	£184	£207	£230	£230	£230	£230	£1748	49.5
Cascade testing	£182	£182	£182	£91	£91	£91	£91	£0	£0	£0	£910	25.7
Annual review meetings	£0	£23	£46	£69	£81	£92	£104	£109	£109	£109	£742	21.0
Specialist referrals	£27	£27	£27	£14	£14	£14	£14	£0	£0	£0	£135	3.8
Value of coronary events avoided	−£17	−£33	−£55	−£60	−£68	−£77	−£85	−£85	−£85	−£85	−£649	−20.7
Total recurrent costs per annum	£238	£291	£338	£266	£291	£316	£340	£242	£242	£242	£2804
Total programme costs excluding clinical savings											£3535	100.0
Benefits
Revascularisations avoided per annum	1	1	3	3	4	4	5	5	5	5	35	33.7
MIs avoided per annum	2	3	5	6	7	8	9	9	9	9	68	66.3
Total (cardiac events avoided)	3	5	8	10	11	12	14	14	14	14	103	100.0
Cost per cardiac event avoided

Atorvastatin on patent	£116	£86	£60	£48	£47	£46	£45	£38	£38	£38
Atorvastatin off patent	£95	£63	£41	£28	£27	£26	£25	£18	£18	£18

Costs are rounded to the nearest £1000 and number of events avoided are rounded to the nearest whole number. This results in the cumulative totals not always being the exact sum of the component numbers in that sum.