Characteristics of included randomised clinical trials
| Characteristics | Di Mario et al (HELP AMI) | Politi et al | Wald et al (PRAMI) |
|---|---|---|---|
| Total number of patients | 69 | 214 | 465 |
| Number of patients on preventive PCI group | 52 | 130 | 234 |
| Number of patients on culprit-only PCI group | 17 | 84 | 231 |
| Primary end points | 12-month incidence of repeat revascularisation (any revascularisation, infarct-related artery as well as non-infarct related artery) | Incidence of MACE defined as cardiac or non-cardiac death, in-hospital death, re-infarction, rehospitalisation for acute coronary syndrome and repeat coronary revascularisation | Composite of death from cardiac causes, non-fatal myocardial infarction or refractory angina |
| Drug eluting stent (%) | 0 | 20 | 71 |
| Antiplatelet therapy | Dual | Dual | Dual |
| Follow-up in months | 12 | Mean 30 | 23 |
| Significant difference between the groups at baseline | Patient with preventive PCI were less often diabetes | None | None |
| Inclusion criteria | STEMI with multivessel disease and 1–3 lesions in non-culprit artery technically amenable to revascularisation by stent | Patients with STEMI with >70% stenosis of ≥2 epicardial arteries or major branches | STEMI with successful treatment of infarct artery and stenosis of 50% or more in one or more coronary arteries other than infarct artery |
| Exclusion criteria | Lesions in vein and arterial grafts, prior PCI or thrombolysis, cardiogenic shock, left main disease | Cardiogenic shock, left main disease, previous CABG, severe valvular heart disease or unsuccessful procedure | Cardiogenic shock, previous CABG, had a non-infarct artery stenosis of 50% or more in the left main stem or the ostia of the left anterior descending and circumflex arteries, only non-infarct stenosis with chronic total occlusion |
| Date of publication | 2004 | 2009 | 2013 |
CABG, coronary artery bypass grafting; MACE, major cardiac adverse events; PCI, percutaneous coronary intervention; STEMI, ST elevation myocardial infarction.