Baseline characteristics
| Baseline | Follow-up | |||||||
|---|---|---|---|---|---|---|---|---|
| Men | Women | Men | Women | |||||
| Miscellaneous | N | Mean (95% CI) | N | Mean (95% CI) | N | Mean (95% CI) | N | Mean (95% CI) |
| Age (years) | 711 | 62 (61 to 63) | 659 | 62 (61 to 63) | 621 | 66 (65 to 66) | 540 | 65 [64 to 66] |
| BSA (m2) | 711 | 1.98 (1.98 to 1.98) | 659 | 1.75 (1.74 to 1.77) | 618 | 1.98 (1.96 to 1.99) | 534 | 1.75 [1.73 to 1.76] |
| AMP (mm Hg) | 711 | 106.57 (105.67 to 107.47) | 659 | 102.01 (101.02 to 103.01) | 619 | 100.06 (99.12 to 101.01) | 535 | 97.3 [96.32 to 98.28] |
| BMI (kg/m2) | 711 | 27.67 (27.47 to 27.87) | 659 | 27.76 (27.5 to 28.01) | 618 | 27.79 (27.57 to 28.02) | 534 | 27.74 [27.44 to 28.06] |
| Echocardiographic parameters | ||||||||
| LV mass (g)* | 691 | 228.64 (224.49 to 232.86) | 460 | 220.77 (215.99 to 225.65) | 460 | 220.77 (215.99 to 225.65) | 425 | 166.34 [162.71 to 170.05] |
| PWD (mm)* | 692 | 11.9 (11.79 to 12.02) | 463 | 11.1 (10.92 to 11.28) | 463 | 11.1 (10.92 to 11.28) | 425 | 10 [9.82 to 10.18] |
| IVSD (mm)* | 695 | 11.87 (11.75 to 12) | 462 | 11.63 (11.44 to 11.81) | 462 | 11.63 (11.44 to 11.81) | 428 | 10.57 [10.4 to 10.74] |
| LAD (mm)* | 683 | 40.08 (39.73 to 40.43) | 579 | 40.92 (40.53 to 41.31) | 579 | 40.92 (40.53 to 41.31) | 506 | 37.81 [37.41 to 38.21] |
| LVDd (mm)* | 693 | 49.39 (48.88 to 49.9) | 464 | 50.17 (49.66 to 50.68) | 464 | 50.17 (49.66 to 50.68) | 426 | 45.85 [45.36 to 46.35] |
| EF (%) | 690 | 62.78 (62.16 to 63.4) | 458 | 65.54 (64.67 to 66.43) | 458 | 65.54 (64.67 to 66.43) | 422 | 67.93 [67.03 to 68.84] |
| Blood parameters | ||||||||
| TNF-R1 (pg/mL) | 672 | 1122.62 (1093.02 to 1153.03) | 614 | 1021.97 (994.12 to 1050.6) | ||||
| hsCRP (mg/L) | 681 | 1.67 (1.54 to 1.8) | 642 | 1.85 (1.7 to 2.01) | 619 | 1.84 (1.71 to 1.99) | 531 | 1.85 [1.7 to 2.01] |
| IL-6 (pg/mL) | 672 | 1.99 (1.83 to 2.17) | 614 | 1.8 (1.65 to 1.97) | ||||
| Creatinine (µmol/L) | 708 | 78.41 (77.33 to 79.52) | 659 | 63.34 (62.48 to 64.22) | 619 | 82.37 (80.82 to 83.96) | 531 | 66.74 [65.66 to 67.83] |
| HDL (mmol/l) | 690 | 3.11 (3.04 to 3.17) | 656 | 3.32 (3.25 to 3.39) | 606 | 3.05 (2.98 to 3.12) | 529 | 3.36 [3.28 to 3.44] |
| HbA1c (%) | 708 | 5.67 (5.61 to 5.73) | 659 | 5.64 (5.59 to 5.7) | 619 | 5.79 (5.73 to 5.84) | 531 | 5.79 [5.73 to 5.84] |
| Numeric values | ||||||||
| Median n of medication | 711 | 4 | 659 | 4 | 619 | 4 | 535 | 4 |
Means are displayed as geometric means with the respecting 95% confidence limits.
*Adjusted for body surface area.
AMP, Arterial mean pressure; BMI, body mass index; BSA, Body surface area; CRP, high-sensitivity C reactive protein; EF, left ventricular ejection fraction; HDL, high-density lipoproteinhs; IL, interleukin 6; IVSD, interventricle septum diameter; LAD, left atrial diastolic diameter; LV, left ventricular mass; LVDd, left ventricular end-diastolic dimension; PWD, posterior wall dimension; TNF, soluble tumour necrosis factor-α receptor 1.