@article {Haddade002157, author = {Raymond N Haddad and S{\'e}bastien Hascoet and Cl{\'e}ment Karsenty and Ali Houeijeh and Alban-Elouen Baruteau and Caroline Ovaert and Estibaliz Valdeolmillos and Zakaria Jalal and Damien Bonnet and Sophie Malekzadeh-Milani}, title = {Multicentre experience with Optimus balloon-expandable cobalt{\textendash}chromium stents in congenital heart disease interventions}, volume = {10}, number = {1}, elocation-id = {e002157}, year = {2023}, doi = {10.1136/openhrt-2022-002157}, publisher = {Archives of Disease in childhood}, abstract = {Objectives To evaluate bare-metal Optimus and polytetrafluoroethylene (PTFE)-covered Optimus-CVS balloon-expandable, cobalt{\textendash}chromium, hybrid cell{\textendash}designed stents in congenital heart disease (CHD) interventions.Methods Retrospective multicentre review of patients with CHD receiving Optimus stents. Stent mechanical behaviour, clinical indications and outcomes were assessed.Results 183 stents (49.2\% XXL/15-ZIG, 33.3\% XL/12-ZIG, 17.5\% L/9-ZIG) were implanted (98.9\% success rate, 2.3\% serious procedural complication rate) in 170 patients (57.6\% men, 64.1\% adults), median age 23.6 years (IQR, 15.2{\textendash}39.2) and weight 63.5 kg (IQR, 47{\textendash}75.7). Indications were right ventricular outflow tract stand-alone stenting or before revalvulation (62.4\%), aortic coarctation treatment (15.3\%), Fontan-circuit fenestration closure (12.4\%) and miscellaneous (10\%). 86/170 (50.6\%) patients had PTFE-covered stenting (50\% prophylactic). In 86/170 (50.6\%) patients with stenotic lesions, median percentage of achieved stent expansion was 93.4\% (IQR, 85.5\%{\textendash}97.7\%), median gradient decreased from 28 mm Hg (IQR, 19{\textendash}41) to 5 mm Hg (IQR, 1{\textendash}9) (p\<0.001), median vessel diameters increased from 13 mm (IQR, 7.9{\textendash}17) to 18.9 mm (IQR, 15.2{\textendash}22) (p\<0.001) and percentage of vessel expansion was 45.2\% (IQR, 19.8\%{\textendash}91.3\%). In 30/36 (83.3\%) patients with graft, median dilation of 2 mm (IQR, 2{\textendash}5) above nominal diameter was achieved. Median stent shortening was 10.9\% (IQR, 6.1{\textendash}15.1) and was associated only with expansion diameter (OR: 0.66, 95\% CI: 0.38 to 0.93). No clinically relevant fracture, stent embolisation or dysfunction occurred on a median follow-up of 9 (IQR, 4{\textendash}14) months.Conclusions Optimus stents are effective tools for transcatheter treatment of simple and complex CHD. Optimus stents{\textquoteright} reliable mechanical behaviour and particular covering design can promote widespread use.Data are available on reasonable request.}, URL = {https://openheart.bmj.com/content/10/1/e002157}, eprint = {https://openheart.bmj.com/content/10/1/e002157.full.pdf}, journal = {Open Heart} }