TY - JOUR T1 - Young athlete’s growing heart: sex differences in cardiac adaptation to exercise training during adolescence JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2022-002155 VL - 10 IS - 1 SP - e002155 AU - Marianne Inngjerdingen Forså AU - Anders W Bjerring AU - Kristina H Haugaa AU - Marit Kristine Smedsrud AU - Sebastian I Sarvari AU - Hege W Landgraff AU - Jostein Hallén AU - Thor Edvardsen Y1 - 2023/01/01 UR - http://openheart.bmj.com/content/10/1/e002155.abstract N2 - Background Athlete’s heart is a condition of exercise-induced cardiac remodelling. Adult male endurance athletes more often remodel beyond reference values. The impact of sex on remodelling through adolescence remains unclear. Paediatric reference values do not account for patient sex or exercise history. We aimed to study the effect of sex on cardiac remodelling throughout adolescence.Methods We recruited 76 male (M) and female (F) 12-year-old cross-country skiers in a longitudinal cohort study. Echocardiography was performed and analysed according to guidelines at age 12 (48 M, 28 F), 15 (34 M, 14 F) and 18 (23 M, 11 F). Repeated echocardiographic measurements were analysed by linear mixed model regression.Results Males displayed greater indexed left ventricular end-diastolic volumes (LV EDVi) from age 12 (M 81±7 vs F 76±7, mL/m², p≤0.01), and progressed further until follow-up at age 18 (M 2.3±9.7 vs F −3.9±4.5 ΔmL/m², p≤0.01). LV EDVi remained above adult upper reference values in both groups. Males increased LV Mass Index from age 12 to 18 (M 33±27 vs F 4±19, Δg/m², p≤0.01). Males displayed LV mass above paediatric reference values at ages 15 and 18. A subset of males (35%) and females (25%) displayed wall thickness above paediatric reference values at age 12. Cardiac function was normal. There was no sex difference in exercise hours.Conclusion Sex-related differences in athlete’s heart were evident from age 12, and progressed throughout adolescence. Remodelling beyond reference values was more frequent than previously reported, particularly affecting males. Age, sex and exercise history may assist clinicians in distinguishing exercise-induced remodelling from pathology in adolescents. ER -