RT Journal Article
SR Electronic
T1 Bioprosthesis in aortic valve replacement: long-term inflammatory response and functionality
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e002065
DO 10.1136/openhrt-2022-002065
VO 9
IS 2
A1 Huitzilihuitl Saucedo-Orozco
A1 Jesus Vargas-Barron
A1 Ricardo Márquez-Velazco
A1 Julio Iván Farjat-Pasos
A1 Karla Susana Martinez-Zavala
A1 Valentin Jiménez-Rojas
A1 Sergio Andres Criales-Vera
A1 Jose Antonio Arias-Godínez
A1 Giovanni Fuentevilla-Alvarez
A1 Veronica Guarner-Lans
A1 Israel Perez-Torres
A1 Gabriela Melendez-Ramirez
A1 Tomas Efrain Sanchez Perez
A1 Maria Elena Soto
YR 2022
UL http://openheart.bmj.com/content/9/2/e002065.abstract
AB Background The evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. It is our objectiveMethods In this study, we included a cohort of patients with aortic valve damage treated by AVR with mechanical prosthesis, bio prosthesis and we included a control group.Results We found that IL-4 and osteopontin levels were higher in patients with mechanical vs biological prostheses (p=0.01 and p=0.04, respectively), osteoprotegerin (OPG) levels were decreased (p=0.01), women had lower levels of ET-1 and IL-6, (p=0.02) (p=0.04), respectively. Patients older than 60 years had decreased levels of IL-1ß p<0.001) and a higher concentration of IL-4 p<0.05). IL-1ß, OPG and TNFα were higher in patients with less than 5 years of evolution vs more than 10 years (p=0.004, p=0.02 and p=0.03, respectively). Factors such as age, gender, prosthetic and elevated IL-1B and ET-1 levels are associated with valve dysfunction prosthetic. These results indicate that the inflammatory involvement present prior to valve replacement may be perpetuated by various factors in the long term.Conclusions The findings provide us with the opportunity to effectively treat patients with AVR in the postoperative period, which could prolong the functionality of the bio prostheses.Trial registration number NCT04557345.Data are available on reasonable request. The data are available on reasonable request to the corresponding author.