PT  - JOURNAL ARTICLE
AU  - Huitzilihuitl Saucedo-Orozco
AU  - Jesus Vargas-Barron
AU  - Ricardo Márquez-Velazco
AU  - Julio Iván Farjat-Pasos
AU  - Karla Susana Martinez-Zavala
AU  - Valentin Jiménez-Rojas
AU  - Sergio Andres Criales-Vera
AU  - Jose Antonio Arias-Godínez
AU  - Giovanni Fuentevilla-Alvarez
AU  - Veronica Guarner-Lans
AU  - Israel Perez-Torres
AU  - Gabriela Melendez-Ramirez
AU  - Tomas Efrain Sanchez Perez
AU  - Maria Elena Soto
TI  - Bioprosthesis in aortic valve replacement: long-term inflammatory response and functionality
AID  - 10.1136/openhrt-2022-002065
DP  - 2022 Aug 01
TA  - Open Heart
PG  - e002065
VI  - 9
IP  - 2
4099  - http://openheart.bmj.com/content/9/2/e002065.short
4100  - http://openheart.bmj.com/content/9/2/e002065.full
SO  - Open Heart2022 Aug 01; 9
AB  - Background The evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. It is our objectiveMethods In this study, we included a cohort of patients with aortic valve damage treated by AVR with mechanical prosthesis, bio prosthesis and we included a control group.Results We found that IL-4 and osteopontin levels were higher in patients with mechanical vs biological prostheses (p=0.01 and p=0.04, respectively), osteoprotegerin (OPG) levels were decreased (p=0.01), women had lower levels of ET-1 and IL-6, (p=0.02) (p=0.04), respectively. Patients older than 60 years had decreased levels of IL-1ß p<0.001) and a higher concentration of IL-4 p<0.05). IL-1ß, OPG and TNFα were higher in patients with less than 5 years of evolution vs more than 10 years (p=0.004, p=0.02 and p=0.03, respectively). Factors such as age, gender, prosthetic and elevated IL-1B and ET-1 levels are associated with valve dysfunction prosthetic. These results indicate that the inflammatory involvement present prior to valve replacement may be perpetuated by various factors in the long term.Conclusions The findings provide us with the opportunity to effectively treat patients with AVR in the postoperative period, which could prolong the functionality of the bio prostheses.Trial registration number NCT04557345.Data are available on reasonable request. The data are available on reasonable request to the corresponding author.