RT Journal Article SR Electronic T1 Predictors of post-TAVI conduction abnormalities in patients with bicuspid aortic valves JF Open Heart JO Open Heart FD British Cardiovascular Society SP e001995 DO 10.1136/openhrt-2022-001995 VO 9 IS 2 A1 Giulia Esposito A1 Niraj Kumar A1 Francesca Pugliese A1 Max Sayers A1 Anthony WC Chow A1 Simon Kennon A1 Mick Ozkor A1 Anthony Mathur A1 Andreas Baumbach A1 Guy Lloyd A1 Aigerim Mullen A1 Andrew Cook A1 Michael Mullen A1 Kush P Patel YR 2022 UL http://openheart.bmj.com/content/9/2/e001995.abstract AB Objectives This study evaluates predictors of conduction abnormalities (CA) following transcatheter aortic valve implantation (TAVI) in patients with bicuspid aortic valves (BAV).Background TAVI is associated with CA that commonly necessitate a permanent pacemaker. Predictors of CA are well established among patients with tricuspid aortic valves but not in those with BAV.Methods This is a single-centre, retrospective, observational study of patients with BAV treated with TAVI. Pre-TAVI ECG and CT scans and procedural characteristics were evaluated in 58 patients with BAV. CA were defined as a composite of high-degree atrioventricular block, new left bundle branch block with a QRS >150 ms or PR >240 ms and right bundle branch block with new PR prolongation or change in axis. Predictors of CA were identified using regression analysis and optimum cut-off values determined using area under the receiver operating characteristic curve analysis.Results CA occurred in 35% of patients. Bioprosthesis implantation depth, the difference between membranous septum (MS) length and implantation depth (δMSID) and device landing zone (DLZ) calcification adjacent to the MS were identified as univariate predictors of CA. The optimum cut-off for δMSID was 1.25 mm. Using this cut-off, low δMSID and DLZ calcification adjacent to MS predicted CA, adjusted OR 8.79, 95% CI 1.88 to 41.00; p=0.01. Eccentricity of the aortic valve annulus, type of BAV and valve calcium quantity and distribution did not predict CA.Conclusions In BAV patients undergoing TAVI, short δMSID and DLZ calcification adjacent to MS are associated with an increased risk of CA.No data are available. Data for this study are not available for sharing due to confidentiality reasons.