TY - JOUR T1 - Impact of elevated left ventricular filling pressure on long-term outcomes after transcatheter aortic valve replacement JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2022-002015 VL - 9 IS - 1 SP - e002015 AU - Raunak M Nair AU - Sanchit Chawla AU - Beni Verma AU - Sachin Kumar AU - Ossama Abou Hassan AU - Bindesh Ghimire AU - Hassan Mehmood Lak AU - Johnny Chahine AU - James Yun AU - Rishi Puri AU - Grant W Reed AU - Amar Krishnaswamy AU - Serge C Harb AU - Samir Kapadia Y1 - 2022/06/01 UR - http://openheart.bmj.com/content/9/1/e002015.abstract N2 - Background Increase in left ventricular filling pressure (FP) and diastolic dysfunction are established consequences of progressive aortic stenosis (AS). However, the impact of elevated FP as detected by pretranscatheter aortic valve replacement (TAVR) echocardiogram on long-term outcomes after TAVR remains unclear.Objective To understand the impact of elevated FP in patients with severe AS who undergo TAVR.Methods This was a retrospective study of all patients who underwent TAVR between 1 January 2014 and 31 December 2017. The presence of elevated FP was determined in accordance with the latest guidelines using the last available comprehensive echocardiogram prior to TAVR.Results Of 983 patients who were included in our study, 422 patients (43%) were found to have elevated FP and 561 patients (57%) had normal FP prior to TAVR. Patients with elevated FP had a mean age of 81.2±8.6 years and were more likely to be males (62%), diabetic (41% vs 35%, p=0.046), and have a higher prevalence of atrial fibrillation (Afib) (53% vs 39%, p<0.001). The 5-year all-cause mortality after TAVR was significantly higher in patients with elevated FP when compared with patients with normal FP (32% vs 24%, p=0.006). The presence of elevated FP, history of Afib and prior PCI emerged as independent predictors of long-term mortality after TAVR.Conclusion Elevated FP is associated with increased mortality in patients with severe AS undergoing TAVR. Assessment of FP should be incorporated into the risk assessment of AS patients to identify those who may benefit from early intervention.No data are available. Due to the patient specific nature of our data, sharing it with individuals outside of this research project will not be possible. ER -