RT Journal Article SR Electronic T1 Impaired right ventricular function in long-term survivors of allogeneic haematopoietic stem-cell transplantation JF Open Heart JO Open Heart FD British Cardiovascular Society SP e001768 DO 10.1136/openhrt-2021-001768 VO 8 IS 2 A1 Richard John Massey A1 Phoi Phoi Diep A1 Marta Maria Burman A1 Anette Borger Kvaslerud A1 Lorentz Brinch A1 Svend Aakhus A1 Lars Gullestad A1 Ellen Ruud A1 Jan Otto Beitnes YR 2021 UL http://openheart.bmj.com/content/8/2/e001768.abstract AB Aims Survivors of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) are at higher risk of cardiovascular disease. We aimed to describe right ventricular (RV) systolic function and risk factors for RV dysfunction in long-term survivors of allo-HSCT performed in their youth.Methods and results This cohort included 103 survivors (53% female), aged (mean±SD) 17.6±9.5 years at allo-HSCT, with a follow-up time of 17.2±5.5 years. Anthracyclines were used as first-line therapy for 44.7% of the survivors. The RV was evaluated with echocardiography, and found survivors to have reduced RV function in comparison to a group of healthy control subjects: Tricuspid annular plane systolic excursion, (TAPSE, 20.8±3.7 mm vs 24.6±3.8 mm, p<0.001), RV peak systolic velocity (RV-s’, 11.2±2.3 cm/s vs 12.3±2.3 cm/s, p=0.001), fractional area change (FAC, 41.0±5.2% vs 42.2±5.1%, p=0.047) and RV free-wall strain (RVFWS, −27.1±4.2% vs −28.5±3.3%, p=0.043). RV systolic dysfunction (RVSD) was diagnosed in 14 (13.6%), and was strongly associated with progressive left ventricular systolic dysfunction (LVSD). High dosages of anthracyclines were associated with greater reductions in RV and LV function. Multivariable linear regressions confirmed global longitudinal strain to be a significant independent predictor for reduced RV function.Conclusion Impaired RV function was found in long-term survivors of allo-HSCT who were treated in their youth. This was associated with progressive left ventricle dysfunction, and pretransplant therapies with anthracyclines. The occurrence of RVSD was less frequent and was milder than coexisting LVSD in this cohort.Data are available on reasonable request. The datasets generated and/or analysed during the current study are not publicly available due restrictions set by Norwegian Regional Committee for Medical Research Ethics, but are available from the corresponding author on reasonable request.