TY - JOUR T1 - Mortality and ventricular arrhythmia after acute myocarditis: a nationwide registry-based follow-up study JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2021-001806 VL - 8 IS - 2 SP - e001806 AU - Kristian Hay Kragholm AU - Filip Lyng Lindgren AU - Tomas Zaremba AU - Phillip Freeman AU - Niels Holmark Andersen AU - Sam Riahi AU - Manan Pareek AU - Lars Køber AU - Christian Torp-Pedersen AU - Peter Søgaard AU - Andreas Hagendorff AU - Bhupendar Tayal Y1 - 2021/10/01 UR - http://openheart.bmj.com/content/8/2/e001806.abstract N2 - Objective Incidence and severity of acute myocarditis vary significantly in previous reports and there is a lack of epidemiological studies on the short-term risks of mortality, heart failure and ventricular arrhythmias in patients with acute myocarditis. Therefore, study aims were to examine 90-day risks of mortality, heart failure (HF) and ventricular arrhythmias in patients with acute myocarditis in comparison to age-matched and sex-matched background population controls.Methods In this nationwide register-based follow-up study of patients hospitalised with myocarditis between 2002 and 2018 in Denmark, 90-day risks of all-cause mortality, HF, ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation (VF)), cardiac arrest and implantable cardioverter-defibrillator (ICD) implantation were compared with age-matched and sex-matched controls from the background population (1:5 matching). Absolute risks standardised to the age, sex and comorbidity distribution of the entire study population were derived from multivariable Cox regression.Results A total of 2523 patients hospitalised with myocarditis were included. Median age was 48 years (Q1–Q3: 30–69) and 67.7% were men. Comorbidity burden was more pronounced among patients with myocarditis relative to controls. Standardised 90-day all-cause mortality risk was 4.9% for patients with acute myocarditis versus 0.3% for controls (p<0.001). Ninety-day standardised risks for other endpoints were 7.5% versus 0.1% for HF, 1.9% versus <0.1% for VF/VF/arrest risk and 1.6% versus <0.1% for ICD implantation (all p<0.001).Conclusions In this large nationwide register-based follow-up study, patients hospitalised with myocarditis had significantly higher 90-day risks of all-cause mortality, HF, ventricular arrhythmias, cardiac arrest and ICD implantation compared with background population controls.Data may be obtained from a third party and are not publicly available. According to Statistics Denmark regulations, data used for this study cannot be shared, as data is stored on and may not leave secure servers on Statistics Denmark. Access to data on these servers can be granted upon adequate permission. ER -