PT  - JOURNAL ARTICLE
AU  - Jolanda Sabatino
AU  - Salvatore De Rosa
AU  - Isabella Leo
AU  - Antonio Strangio
AU  - Sabrina La Bella
AU  - Sabato Sorrentino
AU  - Annalisa Mongiardo
AU  - Carmen Spaccarotella
AU  - Alberto Polimeni
AU  - Ciro Indolfi
TI  - Early reduction of left atrial function predicts adverse clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
AID  - 10.1136/openhrt-2021-001685
DP  - 2021 Jul 01
TA  - Open Heart
PG  - e001685
VI  - 8
IP  - 2
4099  - http://openheart.bmj.com/content/8/2/e001685.short
4100  - http://openheart.bmj.com/content/8/2/e001685.full
SO  - Open Heart2021 Jul 01; 8
AB  - Aims To investigate the changes in left atrial strain (LAS) after correction of severe aortic stenosis (AS) with transcatheter aortic valve replacement (TAVR) and assess its prognostic impact.Methods and results One hundred consecutive patients with severe symptomatic AS who underwent TAVR at the Magna Graecia University of Catanzaro underwent echocardiographic examination including assessment of LAS before and after TAVR. Independent investigators collected outcome data and information. The primary study outcome was the difference in ΔLAS (postTAVR–preTAVR) between patients those met the main clinical endpoint (a composite of cardiovascular mortality and heart failure hospitalisation) and those not meeting the endpoint.During a median follow-up of 31 months, 35 patients (35%) met the combined clinical endpoint. The difference between LAS post-TAVR and LAS pre-TAVR (ΔLAS) was significantly larger in patients who met the combined endpoint (HR=0.76 (0.67–0.86); p<0.001). Multivariate logistic regression analysis including ΔLAS, EuroSCORE II and left ventricular ejection fraction showed that ΔLAS (HR=0.80, p<0.001) was the only independent predictor of the combined clinical endpoint. Finally, a Kaplan-Maier analysis showed that patients with a ΔLAS above its median value had a significantly better event-free survival compared with those below the median (p<0.001).Conclusions A lower reduction in ΔLAS after TAVR was an independent predictor of the primary composite outcome of cardiovascular death and hospitalisation for heart failure.De-identified participant data are available upon request from Dr Jolanda Sabatino (jolesbt@hotmail.it).