PT - JOURNAL ARTICLE AU - Mok, Jacob AU - Malpartida, Juan Carlos AU - O'Dell, Kimberly AU - Davis, Joshua AU - Gao, Cuilan AU - Manyam, Harish TI - Vascular comorbidities worsen prognosis of patients with heart failure hospitalised with COVID-19 AID - 10.1136/openhrt-2021-001668 DP - 2021 Jun 01 TA - Open Heart PG - e001668 VI - 8 IP - 1 4099 - http://openheart.bmj.com/content/8/1/e001668.short 4100 - http://openheart.bmj.com/content/8/1/e001668.full SO - Open Heart2021 Jun 01; 8 AB - Background Prior diagnosis of heart failure (HF) is associated with increased length of hospital stay (LOS) and mortality from COVID-19. Associations between substance use, venous thromboembolism (VTE) or peripheral arterial disease (PAD) and its effects on LOS or mortality in patients with HF hospitalised with COVID-19 remain unknown.Objective This study identified risk factors associated with poor in-hospital outcomes among patients with HF hospitalised with COVID-19.Methods Case–control study was conducted of patients with prior diagnosis of HF hospitalised with COVID-19 at an academic tertiary care centre from 1 January 2020 to 28 February 2021. Patients with HF hospitalised with COVID-19 with risk factors were compared with those without risk factors for clinical characteristics, LOS and mortality. Multivariate regression was conducted to identify multiple predictors of increased LOS and in-hospital mortality in patients with HF hospitalised with COVID-19.Results Total of 211 patients with HF were hospitalised with COVID-19. Women had longer LOS than men (9 days vs 7 days; p<0.001). Compared with patients without PAD or ischaemic stroke, patients with PAD or ischaemic stroke had longer LOS (7 days vs 9 days; p=0.012 and 7 days vs 11 days, p<0.001, respectively). Older patients (aged 65 and above) had increased in-hospital mortality compared with younger patients (adjusted OR: 1.04; 95% CI 1.00 to 1.07; p=0.036). Prior diagnosis of VTE increased mortality more than threefold in patients with HF hospitalised with COVID-19 (adjusted OR: 3.33; 95% CI 1.29 to 8.43; p=0.011).Conclusion Vascular diseases increase LOS and mortality in patients with HF hospitalised with COVID-19.All data relevant to the study are included in the article or uploaded as supplemental information. Others can reuse and share our data with others as long as they credit and cite us, but not for commercial uses.