RT Journal Article
SR Electronic
T1 Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e001628
DO 10.1136/openhrt-2021-001628
VO 8
IS 1
A1 Kamal Matli
A1 Raymond Farah
A1 Mario Maalouf
A1 Nibal Chamoun
A1 Christy Costanian
A1 Georges Ghanem
YR 2021
UL http://openheart.bmj.com/content/8/1/e001628.abstract
AB Although primarily affecting the respiratory system, COVID-19 causes multiple organ damage. One of its grave consequences is a prothrombotic state that manifests as thrombotic, microthrombotic and thromboembolic events. Therefore, understanding the effect of antiplatelet and anticoagulation therapy in the context of COVID-19 treatment is important. The aim of this rapid review was to highlight the role of thrombosis in COVID-19 and to provide new insights on the use of antithrombotic therapy in its management. A rapid systematic review was performed using preferred reporting items for systematic reviews. Papers published in English on antithrombotic agent use and COVID-19 complications were eligible. Results showed that the use of anticoagulants increased survival and reduced thromboembolic events in patients. However, despite the use of anticoagulants, patients still suffered thrombotic events likely due to heparin resistance. Data on antiplatelet use in combination with anticoagulants in the setting of COVID-19 are quite scarce. Current side effects of anticoagulation therapy emphasise the need to update treatment guidelines. In this rapid review, we address a possible modulatory role of antiplatelet and anticoagulant combination against COVID-19 pathogenesis. This combination may be an effective form of adjuvant therapy against COVID-19 infection. However, further studies are needed to elucidate potential risks and benefits associated with this combination.No data are available.