RT Journal Article
SR Electronic
T1 Does postoperative cognitive decline after coronary bypass affect quality of life?
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e001569
DO 10.1136/openhrt-2020-001569
VO 8
IS 1
A1 Fredrike Blokzijl
A1 Frederik Keus
A1 Saskia Houterman
A1 Willem Dieperink
A1 Iwan C C van der Horst
A1 Michiel F Reneman
A1 Anthony R Absalom
A1 Massimo A Mariani
YR 2021
UL http://openheart.bmj.com/content/8/1/e001569.abstract
AB Objective This study aimed to explore the influence of coronary artery bypass grafting (CABG) on both postoperative cognitive dysfunction and quality of life (QoL) and the association between the two patient-related outcomes.Methods In a prospective, observational cohort study, patients with elective, isolated CABG were included. Cognitive function was assessed using the Cogstate computerised cognitive test battery preoperatively, 3 days and 6 months after surgery. QoL was measured preoperatively and at 6 months using the RAND-36 questionnaire including the Physical Component Score (PCS) and the Mental Component Score (MCS). Regression analysis, with adjustment for confounders, was used to evaluate the association between postoperative cognitive dysfunction and QoL.Results A total of 142 patients were included in the study. Evidence of persistent cognitive dysfunction was observed in 33% of patients after 6 months. At 6 months, the PCS had improved in 59% and decreased in 21% of patients, and the MCS increased in 49% and decreased in 29%. Postoperative cognitive changes were not associated with QoL scores.Conclusions Postoperative cognitive dysfunction and decreased QoL are common 6 months after surgery, although cognitive function and QoL were found to have improved in many patients at 6 months of follow-up. Impaired cognitive function is not associated with impaired QoL at 6 months.Trial registration number NCT03774342.All data relevant to the study are included in the article or uploaded as supplementary information. The data that support the findings in this study are available from the corresponding author (FB) on reasonable request.