RT Journal Article
SR Electronic
T1 COVID-19 and its impact on the cardiovascular system
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e001472
DO 10.1136/openhrt-2020-001472
VO 8
IS 1
A1 Saud Ahmed Khawaja
A1 Poornima Mohan
A1 Richard Jabbour
A1 Theodora Bampouri
A1 Gemma Bowsher
A1 Ahmed M M Hassan
A1 Farhan Huq
A1 Lilit Baghdasaryan
A1 Brian Wang
A1 Amarjit Sethi
A1 Sayan Sen
A1 Ricardo Petraco
A1 Neil Ruparelia
A1 Sukhjinder Nijjer
A1 Iqbal Malik
A1 Rodney Foale
A1 Michael Bellamy
A1 Jaspal Kooner
A1 Bushra Rana
A1 Graham Cole
A1 Nilesh Sutaria
A1 Gajen Kanaganayagam
A1 Petros Nihoyannopoulos
A1 Kevin Fox
A1 Carla Plymen
A1 Punam Pabari
A1 Luke Howard
A1 Rachel Davies
A1 Gulammehdi Haji
A1 Francesco Lo Giudice
A1 Prapa Kanagaratnam
A1 Jon Anderson
A1 Andrew Chukwuemeka
A1 Ramzi Khamis
A1 Amanda Varnava
A1 Christopher S R Baker
A1 Darrel Parthipan Francis
A1 Perviz Asaria
A1 Rasha Al-Lamee
A1 Ghada W Mikhail
YR 2021
UL http://openheart.bmj.com/content/8/1/e001472.abstract
AB Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development of cardiovascular complications in the initial cohort of SARS-CoV-2 positive patients at Imperial College Healthcare National Health Service Trust, UK.Methods We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7 March to 7 April 2020. Patient data were collected for baseline demographics, comorbidities and in-hospital outcomes, especially relating to cardiovascular intervention.Results Mean age was 67.4±16.1 years and 62.2% (n=310) were male. 64.1% (n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4% (n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%, p<0.001). Only four COVID-19 patients had invasive coronary angiography, two underwent percutaneous coronary intervention and one required a permanent pacemaker implantation. 7.0% (n=35) of patients had an inpatient echocardiogram. Acute myocardial injury (OR 2.39, 95% CI 1.31 to 4.40, p=0.005) and history of hypertension (OR 1.88, 95% CI 1.01 to 3.55, p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for.Conclusion Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention.