TY - JOUR T1 - COVID-19 and its impact on the cardiovascular system JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2020-001472 VL - 8 IS - 1 SP - e001472 AU - Saud Ahmed Khawaja AU - Poornima Mohan AU - Richard Jabbour AU - Theodora Bampouri AU - Gemma Bowsher AU - Ahmed M M Hassan AU - Farhan Huq AU - Lilit Baghdasaryan AU - Brian Wang AU - Amarjit Sethi AU - Sayan Sen AU - Ricardo Petraco AU - Neil Ruparelia AU - Sukhjinder Nijjer AU - Iqbal Malik AU - Rodney Foale AU - Michael Bellamy AU - Jaspal Kooner AU - Bushra Rana AU - Graham Cole AU - Nilesh Sutaria AU - Gajen Kanaganayagam AU - Petros Nihoyannopoulos AU - Kevin Fox AU - Carla Plymen AU - Punam Pabari AU - Luke Howard AU - Rachel Davies AU - Gulammehdi Haji AU - Francesco Lo Giudice AU - Prapa Kanagaratnam AU - Jon Anderson AU - Andrew Chukwuemeka AU - Ramzi Khamis AU - Amanda Varnava AU - Christopher S R Baker AU - Darrel Parthipan Francis AU - Perviz Asaria AU - Rasha Al-Lamee AU - Ghada W Mikhail Y1 - 2021/03/01 UR - http://openheart.bmj.com/content/8/1/e001472.abstract N2 - Objectives The clinical impact of SARS-CoV-2 has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development of cardiovascular complications in the initial cohort of SARS-CoV-2 positive patients at Imperial College Healthcare National Health Service Trust, UK.Methods We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7 March to 7 April 2020. Patient data were collected for baseline demographics, comorbidities and in-hospital outcomes, especially relating to cardiovascular intervention.Results Mean age was 67.4±16.1 years and 62.2% (n=310) were male. 64.1% (n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4% (n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%, p<0.001). Only four COVID-19 patients had invasive coronary angiography, two underwent percutaneous coronary intervention and one required a permanent pacemaker implantation. 7.0% (n=35) of patients had an inpatient echocardiogram. Acute myocardial injury (OR 2.39, 95% CI 1.31 to 4.40, p=0.005) and history of hypertension (OR 1.88, 95% CI 1.01 to 3.55, p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for.Conclusion Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention. ER -