@article {Pococke001499, author = {Stuart Pocock and David B Brieger and Ruth Owen and Jiyan Chen and Mauricio G Cohen and Shaun Goodman and Christopher B Granger and Jos{\'e} C Nicolau and Tabassome Simon and Dirk Westermann and Satoshi Yasuda and Katarina Hedman and Carl Mellstr{\"o}m and Karolina Andersson Sundell and Richard Grieve}, title = {Health-related quality of life 1{\textendash}3 years post-myocardial infarction: its impact on prognosis}, volume = {8}, number = {1}, elocation-id = {e001499}, year = {2021}, doi = {10.1136/openhrt-2020-001499}, publisher = {Archives of Disease in childhood}, abstract = {Objective To assess associations of health-related quality of life (HRQoL) with patient profile, resource use, cardiovascular (CV) events and mortality in stable patients post-myocardial infarction (MI).Methods The global, prospective, observational TIGRIS Study enrolled 9126 patients 1{\textendash}3 years post-MI. HRQoL was assessed at enrolment and 6-month intervals using the patient-reported EuroQol-5 dimension (EQ-5D) questionnaire, with scores anchored at 0 (worst possible) and 1 (perfect health). Resource use, CV events and mortality were recorded during 2-years{\textquoteright} follow-up. Regression models estimated the associations of index score at enrolment with patient characteristics, resource use, CV events and mortality over 2-years{\textquoteright} follow-up.Results Among 8978 patients who completed the EQ-5D questionnaire, 52\% reported {\textquoteleft}some{\textquoteright} or {\textquoteleft}severe{\textquoteright} problems on one or more health dimensions. Factors associated with a lower index score were: female sex, older age, obesity, smoking, higher heart rate, less formal education, presence of comorbidity (eg, angina, stroke), emergency room visit in the previous 6 months and non-ST-elevation MI as the index event. Compared with an index score of 1 at enrolment, a lower index score was associated with higher risk of all-cause death, with an adjusted rate ratio of 3.09 (95\% CI 2.20 to 4.31), and of a CV event, with a rate ratio of 2.31 (95\% CI 1.76 to 3.03). Patients with lower index score at enrolment had almost two times as many hospitalisations over 2-years{\textquoteright} follow-up.Conclusions Clinicians managing patients post-acute coronary syndrome should recognise that a poorer HRQoL is clearly linked to risk of hospitalisations, major CV events and death.Trial registration number ClinicalTrials.gov Registry (NCT01866904) (https://clinicaltrials.gov).}, URL = {https://openheart.bmj.com/content/8/1/e001499}, eprint = {https://openheart.bmj.com/content/8/1/e001499.full.pdf}, journal = {Open Heart} }