RT Journal Article
SR Electronic
T1 Characteristics and outcomes of young patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: retrospective analysis in a multiethnic Asian population
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e001437
DO 10.1136/openhrt-2020-001437
VO 8
IS 1
A1 Benjamin WL Tung
A1 Zhe Yan Ng
A1 William Kristanto
A1 Kalyar Win Saw
A1 Siew-Pang Chan
A1 Winnie Sia
A1 Koo Hui Chan
A1 Mark Chan
A1 William Kong
A1 Ronald Lee
A1 Joshua P Loh
A1 Adrian F Low
A1 Kian Keong Poh
A1 Edgar Tay
A1 Huay Cheem Tan
A1 Tiong-Cheng Yeo
A1 Poay Huan Loh
YR 2021
UL http://openheart.bmj.com/content/8/1/e001437.abstract
AB Objective ST segment elevation myocardial infarction (STEMI) is associated with significant mortality leading to loss of productive life years, especially in younger patients. This study aims to compare the characteristics and outcomes of young versus older patients with STEMI undergoing primary percutaneous coronary intervention (PPCI) to help focus public health efforts in STEMI prevention.Methods Data from the Coronary Care Unit database of the National University Hospital, Singapore from July 2015 to June 2019 were reviewed. Patients were divided into young (<50 years old) or older (≥50 years old) groups.Results Of the 1818 consecutive patients with STEMI who underwent PPCI, 465 (25.6%) were <50 years old. Young compared with older patients were more likely to be male, current smokers, of Indian ethnicity, have family history of ischaemic heart disease (IHD) and had lower 1 year mortality (3.4% vs 10.4%, p<0.0001). Although diabetes, hypertension or dyslipidaemia was less common among young patients, the prevalence of having any one of these risk factors was high in the range of 28% to 38%. Age was an independent predictor of mortality in the older but not younger patients with STEMI, and diabetes showed a trend towards mortality in both groups.Conclusion Young patients with STEMI are more often smokers, of Indian ethnicity and had family history of IHD, although cardiometabolic risk factors are also prevalent. Mortality is lower, but not negligible, among the young patients with STEMI. Public health efforts are needed to reduce the prevalence of these risk factors among the constitutionally susceptible population.