TY - JOUR T1 - Sex differences in patients undergoing transcatheter aortic valve replacement in Asia JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2020-001541 VL - 8 IS - 1 SP - e001541 AU - Paul T L Chiam AU - Kentaro Hayashida AU - Yusuke Watanabe AU - Wei-Hsian Yin AU - Hsien-Li Kao AU - Michael K Y Lee AU - Fabio Enrique Posas AU - Mann Chandavimol AU - Wacin Buddhari AU - Timothy C Dy AU - Ngoc Quang Nguyen AU - Won Jang Kim AU - Kiyuk Chang AU - Mao-Shin Lin AU - Yat-Yin Lam AU - Hung Manh Pham AU - Shaiful Azmi Yahaya AU - Kay Woon Ho AU - Wenzhi Pan AU - Xian-bao Liu AU - Jian'an Wang AU - Hyo Soo Kim AU - Mao Chen Y1 - 2021/01/01 UR - http://openheart.bmj.com/content/8/1/e001541.abstract N2 - Objectives Transcatheter aortic valve replacement (TAVR) is increasingly performed. Physically small Asians have smaller aortic root and peripheral vessel anatomy. The influence of gender of Asian patients undergoing TAVR is unknown and may affect outcomes. The aim of this study was to assess sex differences in Asian patients undergoing TAVR.Methods Patients undergoing TAVR from eight countries were enrolled. In this retrospective analysis, we examined differences in characteristics, 30-day clinical outcomes and 1-year survival between female and male Asian patients.Results Eight hundred and seventy-three patients (54.4% women) were included. Women were older, smaller and had less coronary artery and lung disease but tended to have higher logistic EuroSCOREs. Smaller prostheses were used more often in women. Major vascular complications occurred more frequently in women (5.5% vs 1.8%, p<0.01); however, 30-day stroke and mortality (women vs men: 1.5% vs 1.6%, p=0.95% and 4.3% vs 3.4%, p=0.48) were similar. Functional status improvement was significant and comparable between the sexes. Conduction disturbance and permanent pacemaker requirements (11.2% vs 9.0%, p=0.52) were also similar as was 1-year survival (women vs men: 85.6% vs 88.2%, p=0.25). The only predictors of 30-day mortality were major vascular injury in women and age in men.Conclusions Asian women had significantly smaller stature and anatomy with some differences in clinical profiles. Despite more frequent major vascular complications, women had similar 30-day stroke or mortality rates. Functional status improvement was significant and comparable between the sexes. Conduction disturbance and permanent pacemaker requirements were similar as was 1-year survival. ER -