PT  - JOURNAL ARTICLE
AU  - Odayme Quesada
AU  - Ki Park
AU  - Janet Wei
AU  - Eileen Handberg
AU  - Chrisandra Shufelt
AU  - Margo Minissian
AU  - Galen Cook-Wiens
AU  - Parham Zarrini
AU  - Christine Pacheco
AU  - Balaji Tamarappoo
AU  - Louise E J Thomson
AU  - Daniel S Berman
AU  - Carl J Pepine
AU  - Noel Bairey Merz
TI  - Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy
AID  - 10.1136/openhrt-2020-001273
DP  - 2020 Aug 01
TA  - Open Heart
PG  - e001273
VI  - 7
IP  - 2
4099  - http://openheart.bmj.com/content/7/2/e001273.short
4100  - http://openheart.bmj.com/content/7/2/e001273.full
SO  - Open Heart2020 Aug 01; 7
AB  - Aims Hypertensive disorders of pregnancy (HDP) predict future cardiovascular events. We aim to investigate relations between HDP history and subsequent hypertension (HTN), myocardial structure and function, and late gadolinium enhancement (LGE) scar.Methods and results We evaluated a prospective cohort of women with suspected ischaemia with no obstructive coronary artery disease (INOCA) who underwent stress/rest cardiac magnetic resonance imaging (cMRI) with LGE in the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Self-reported history of pregnancy and HDP (gestational HTN, pre-eclampsia, toxaemia and eclampsia) were collected at enrollment. In our cohort of 346, 20% of women report a history of HDP. HDP history was associated with 3.2-fold increased odds of HTN. Women with a history of both HDP and HTN had higher cMRI measured left ventricular (LV) mass compared with women with HDP only (99.4±2.6 g vs 87.7±3.2 g, p=0.02). While we found a similar frequency of LGE scar, we observed a trend towards increased LGE scar size (5.1±3.4 g vs 8.0±3.4 g, p=0.09) among the women with HDP history compared to women without.Conclusion In a high-risk cohort of women with suspected INOCA, 20% had a history of HDP. Women with HDP history were more likely to develop HTN. Our study demonstrates higher LV mass in women with HDP and concomitant HTN. Although the presence of LGE scar was not different in women with and without HDP history, we observed a trend towards larger scar size in women with HDP. Future studies are needed to better assess the relationship of HDP and cardiac morphology and LGE scarring in a larger cohort of women.