TY - JOUR T1 - Sibling history is associated with heart failure after a first myocardial infarction JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2019-001143 VL - 7 IS - 1 SP - e001143 AU - Charlotte Glinge AU - Louise Oestergaard AU - Reza Jabbari AU - Sara Rossetti AU - Regitze Skals AU - Lars Køber AU - Thomas Engstrøm AU - Connie R Bezzina AU - Christian Torp-Pedersen AU - Gunnar Gislason AU - Jacob Tfelt-Hansen Y1 - 2020/03/01 UR - http://openheart.bmj.com/content/7/1/e001143.abstract N2 - Objective Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI.Methods Through nationwide registries, we identified all individuals aged 18–50 years hospitalised with first MI from 1997 to 2016 in Denmark. We identified 13 810 patients with MI, and the cohort was followed until HF diagnosis, second MI, 3 years after index MI, emigration, death or the end of 2016, whichever occurred first. HRs were estimated by Cox hazard regression models adjusted for sex, age, calendar year and comorbidities (reference: patients with no family history of MI).Results After adjustment, we observed an increased risk of MI-induced HF for those having a sibling with MI with HF (HR 2.05, 95% CI 1.02 to 4.12). Those having a sibling with MI without HF also had a significant, but lower increased risk of HF (HR 1.39, 95% CI 1.05 to 1.84). Parental history of MI with or without HF was not associated with HF.Conclusion In this nationwide cohort, sibling history of MI with or without HF was associated with increased risk of HF after first MI, while a parental family history was not, suggesting that shared environmental factors may predominate in the determination of risk for developing HF. ER -