PT  - JOURNAL ARTICLE
AU  - Mohammed Yousufuddin
AU  - Ye Zhu
AU  - Ruaa Al Ward
AU  - Jessica Peters
AU  - Taylor Doyle
AU  - Kelsey L Jensen
AU  - Zhen Wang
AU  - Mohammad Hassan Murad
TI  - Association of hyperlipidaemia with 5-year survival after hospitalisation for acute myocardial infarction: a propensity score matched analysis
AID  - 10.1136/openhrt-2019-001163
DP  - 2020 Mar 01
TA  - Open Heart
PG  - e001163
VI  - 7
IP  - 1
4099  - http://openheart.bmj.com/content/7/1/e001163.short
4100  - http://openheart.bmj.com/content/7/1/e001163.full
SO  - Open Heart2020 Mar 01; 7
AB  - Objectives The primary objective was to examine the association between hyperlipidaemia (HLP) and 5-year survival after incident acute myocardial infarction (AMI). The secondary objectives were to assess the effect of HLP on survival to discharge across patient subgroups, and the impact of statin prescription, intensity and long-term statin adherence on 5-year survival.Methods Retrospective cohort study of 7071 patients hospitalised for AMI at Mayo Clinic from 2001 through 2011. Of these, 2091 patients with HLP (age (mean±SD) 69.7±13.5) were propensity score matched to 2091 patients without HLP (age 70.6±14.2).Results In matched patients, HLP was associated with higher rate of survival to discharge than no HLP (95% vs 91%; log-rank <0.0001). At year 5, the adjusted HR for all-cause mortality in patients with HLP versus no HLP was 0.66 (95% CI 0.58–0.74), and patients with prescription statin versus no statin was 0.24 (95% CI 0.21 to 0.28). The mean survival was 0.35 year greater in patients with HLP than in those with no HLP (95% CI 0.25 to 0.46). Patients with HLP gained on an average 0.17 life year and those treated with statin 0.67 life year at 5 years after AMI. The benefit of concurrent HLP was consistent across study subgroups.Conclusions In patients with AMI, concomitant HLP was associated with increased survival and a net gain in life years, independent of survival benefit from statin therapy. The results also reaffirm the role of statin prescription, intensity and adherence in reducing the mortality after incident AMI.