RT Journal Article
SR Electronic
T1 Exploration of pathophysiological pathways for incident atrial fibrillation using a multiplex proteomic chip
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e001190
DO 10.1136/openhrt-2019-001190
VO 7
IS 1
A1 John Molvin
A1 Amra Jujic
A1 Olle Melander
A1 Manan Pareek
A1 Lennart Råstam
A1 Ulf Lindblad
A1 Bledar Daka
A1 Margret Leosdottir
A1 Peter Nilsson
A1 Michael Olsen
A1 Martin Magnusson
YR 2020
UL http://openheart.bmj.com/content/7/1/e001190.abstract
AB Objective Atrial fibrillation (AF) is the most common arrhythmia and associated with increased morbidity and mortality. Its increasing prevalence calls for novel biomarkers to identify underlying pathophysiological mechanisms as well as patients at risk.Methods Plasma samples from 1694 individuals from the Swedish population-based Malmö Preventive Project (mean age 69.5 years; 29.3% female; mean follow-up time 9.7±3.1 years) were analysed with the Olink proximity extension assay CVD III panel consisting of 92 proteins to identify proteins associated with incident AF or atrial flutter, referred to as incident AF. Incident cases of AF (n=278) were retrieved by linkage to the registers. Participants were followed until the first episode of AF or until censoring by death or emigration. Bonferroni-corrected multivariable Cox regression models adjusted for known risk factors were used to explore possible associations of the 92 proteins and incidence of AF.Results Multivariable Cox regression analyses of 11 proteins associated with incident AF (mean follow-up time 9.7±3.1 years) after Bonferroni correction confirmed N-terminal pro-B-type natriuretic peptide (HR per 1 SD increment (95% CI) 1.80 (1.58 to 2.04); p=1.2×10−19) as risk marker of incident AF. Further, matrix metalloproteinase-2 (1.22 (1.07 to 1.39); p=0.002) and osteopontin (1.27 (1.12 to 1.44); p=2.7×10−4) were associated with incident AF at follow-up independently of traditional risk markers and NT-proBNP.Conclusion In a general Swedish population, we confirmed the well-known association of NT-proBNP with incident AF and also identified matrix metalloproteinase-2 and osteopontin as novel risk markers for incident AF, independently of traditional risk factors and NT-proBNP.