RT Journal Article
SR Electronic
T1 Association of smoking and right ventricular function in middle age: CARDIA study
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e001270
DO 10.1136/openhrt-2020-001270
VO 7
IS 1
A1 Henrique T Moreira
A1 Anderson C Armstrong
A1 Chike C Nwabuo
A1 Henrique D Vasconcellos
A1 Andre Schmidt
A1 Ravi K Sharma
A1 Bharath Ambale-Venkatesh
A1 Mohammad R Ostovaneh
A1 Catarina I Kiefe
A1 Cora E Lewis
A1 Pamela J Schreiner
A1 Stephen Sidney
A1 Kofo O Ogunyankin
A1 Samuel S Gidding
A1 Joao A C Lima
YR 2020
UL http://openheart.bmj.com/content/7/1/e001270.abstract
AB Objective To evaluate the association of cigarette smoking and right ventricular (RV) systolic and diastolic functions in a population-based cohort of individuals at middle age.Methods This cross-sectional study included participants who answered the smoking questionnaire and underwent echocardiography at the Coronary Artery Risk Development in Young Adulthood year 25 examination. RV systolic function was assessed by echocardiographic-derived tricuspid annular plane systolic excursion (TAPSE) and by right ventricular peak systolic velocity (RVS’), while RV diastolic function was evaluated by early right ventricular tissue velocity (RVE’). Multivariable linear regression models assessed the relationship of smoking with RV function, adjusting for age, sex, race, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes mellitus, alcohol consumption, pulmonary function, left ventricular systolic and diastolic function and coronary artery calcium score.Results A total of 3424 participants were included. The mean age was 50±4 years; 57% were female; and 53% were black. There were 2106 (61%) never smokers, 750 (22%) former smokers and 589 (17%) current smokers. In the multivariable analysis, current smokers had significantly lower TAPSE (β=−0.082, SE=0.031, p=0.008), RVS’ (β=−0.343, SE=0.156, p=0.028) and RVE’ (β=−0.715, SE=0.195, p<0.001) compared with never smokers. Former smokers had a significantly lower RVE’ compared with never smokers (β=−0.414, SE=0.162, p=0.011), whereas no significant difference in RV systolic function was found between former smokers and never smokers.Conclusions In a large multicenter community-based biracial cohort of middle-aged individuals, smoking was independently related to both worse RV systolic and diastolic functions.