RT Journal Article SR Electronic T1 ‘Big issues’ in neurodevelopment for children and adults with congenital heart disease JF Open Heart JO Open Heart FD British Cardiovascular Society SP e000998 DO 10.1136/openhrt-2018-000998 VO 6 IS 2 A1 Charlotte E Verrall A1 Gillian M Blue A1 Alison Loughran-Fowlds A1 Nadine Kasparian A1 Jozef Gecz A1 Karen Walker A1 Sally L Dunwoodie A1 Rachael Cordina A1 Gary Sholler A1 Nadia Badawi A1 David Winlaw YR 2019 UL http://openheart.bmj.com/content/6/2/e000998.abstract AB It is established that neurodevelopmental disability (NDD) is common in neonates undergoing complex surgery for congenital heart disease (CHD); however, the trajectory of disability over the lifetime of individuals with CHD is unknown. Several ‘big issues’ remain undetermined and further research is needed in order to optimise patient care and service delivery, to assess the efficacy of intervention strategies and to promote best outcomes in individuals of all ages with CHD. This review article discusses ‘gaps’ in our knowledge of NDD in CHD and proposes future directions.