RT Journal Article
SR Electronic
T1 Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e000896
DO 10.1136/openhrt-2018-000896
VO 5
IS 2
A1 Masatoshi Minamisawa
A1 Jun Koyama
A1 Ayako Kozuka
A1 Takashi Miura
A1 Tatsuya Saigusa
A1 Soichiro Ebisawa
A1 Hirohiko Motoki
A1 Ayako Okada
A1 Uichi Ikeda
A1 Koichiro Kuwahara
YR 2018
UL http://openheart.bmj.com/content/5/2/e000896.abstract
AB Objective Myocardial early systolic lengthening (ESL) duration is prolonged in patients with coronary artery disease (CAD). However, the relationship between the fractional flow reserve (FFR), the current gold standard for evaluating physiological myocardial ischaemia, and ESL has not been studied. The aims of this study were to investigate whether left ventricular (LV) ESL duration could identify patients with CAD, and to examine the relationship between FFR and LV ESL duration.Methods In this single-centre, cross-sectional, prospective study of 75 patients with suspected or known CAD, we performed two-dimensional speckle tracking echocardiography at rest on the day before coronary angiography or percutaneous coronary intervention. Apical 3 views were used to examine ESL duration, defined as time from onset of the Q wave to maximum myocardial systolic lengthening.Results Thirty-five patients had non-significant stenosis. Forty patients with CAD underwent FFR testing: 17 had an FFR≥0.8 and 23 had an FFR<0.8. Global ESL duration was 20.9±22.2 ms in patients with non-significant stenosis, 36.4±23.2 ms in patients with FFR≥0.8 and 39.6±29.5 ms in patients with FFR<0.8 (p=0.020). However, global and regional ESL durations were not significantly correlated with FFR and demonstrated poor reproducibility.Conclusion Although myocardial ESL duration was significantly prolonged in patients with CAD compared with patients without CAD, ESL at rest showed poor reproducibility, and this new parameter did not predict FFR in patients with suspected CAD.